Journal
EUROPEAN JOURNAL OF CELL BIOLOGY
Volume 101, Issue 2, Pages -Publisher
ELSEVIER GMBH
DOI: 10.1016/j.ejcb.2022.151206
Keywords
Adipose tissue; Adipose-derived stromal cells; White adipocyte; Beige adipocyte; Aging; microRNA
Categories
Funding
- Italian Government - Ministero dell'Istruzione
- dell'Universita e Della Ricerca Scientifica
Ask authors/readers for more resources
In this study, it was found that adipose-derived stromal cells (ASC) in mice undergo transcriptional changes from brown/beige-like to white-like with age. These changes may be related to alterations in the activity of the transcription factors E2F1 and NFkB.
Multipotent stem cells persist within the stromal vascular fraction (SVF) of adipose tissue during adulthood. These cells, commonly referred to as adipose-derived stromal cells (ASC), have been extensively investigated over the past years as a promising therapeutic tool based on their regenerative and immunomodulatory properties. However, how ASC might mirror the age-related alteration of the fat they reside in remains unclear. Herein, we show that inguinal adipose tissue in mice turns from brown/beige- to white-like with age and resident ASC readily mirror these changes both at mRNA and microRNA transcriptional level. Mechanistically, our data suggest that these brown/age-related changes in ASC transcription rely on changes in the activity of E2F1 and NFkB transcription factors.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available