Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 84, Issue -, Pages 45-67Publisher
ELSEVIER
DOI: 10.1016/j.addr.2014.11.018
Keywords
Bone regeneration; Drug delivery; Temporal regulation; Spatial regulation; Biomaterials patterning
Categories
Funding
- National Institutes of Health [R01AR063194, R56DE022376, R21AR061265, R01AR053733]
- Department of Defense Congressionally Directed Medical Research Programs [OR110196]
- AO Foundation
- Ellison Medical Foundation
- NSF
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Limitations of current treatment options for critical size bone defects create a significant clinical need for tissue engineered bone strategies. This review describes how control over the spatiotemporal delivery of growth factors, nucleic adds, and drugs and small molecules may aid in recapitulating signals present in bone development and healing, regenerating interfaces of bone with other connective tissues, and enhancing vascularization of tissue engineered bone. State-of-the-art technologies used to create spatially controlled patterns of bioactive factors on the surfaces of materials, to build up 3D materials with patterns of signal presentation within their bulk, and to pattern bioactive factor delivery after scaffold fabrication are presented, highlighting their applications in bone tissue engineering. As these techniques improve in areas such as spatial resolution and speed of patterning, they will continue to grow in value as model systems for understanding cell responses to spatially regulated bioactive factor signal presentation in vitro, and as strategies to investigate the capacity of the defined spatial arrangement of these signals to drive bone regeneration in vivo. (C) 2014 Elsevier B.V. All rights reserved.
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