4.7 Article

There is no origin to SARS-CoV-2

Journal

ENVIRONMENTAL RESEARCH
Volume 207, Issue -, Pages -

Publisher

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.envres.2021.112173

Keywords

SARS-CoV-2; COVID-19; Coronavirus; Emerging diseases; Origin; Evolution

Funding

  1. Institut de Recherche pour le Developpement
  2. Aix-Marseille University
  3. CIRAD (Centre de Cooperation Internationale en Recherche Agronomique pour le Developpement)
  4. University of Montpellier
  5. CNRS (Centre National de la Recherche Scientifique)

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Since the COVID-19 pandemic began in 2020, the origin of the virus has been heavily debated. The two main hypotheses, natural spillover and laboratory-leak origin, have supporters who build arguments against each other. However, the biased nature of the original question itself is the main problem. The origin of viruses is not determined, but rather a process of evolution and selection.
Since the beginning of the COVID-19 pandemic in 2020 caused by SARS-CoV-2, the question of the origin of this virus has been a highly debated issue. Debates have been, and are still, very disputed and often violent between the two main hypotheses: a natural origin through the spillover model or a laboratory-leak origin. Tenants of these two options are building arguments often based on the discrepancies of the other theory. The main problem is that it is the initial question of the origin itself which is biased. Charles Darwin demonstrated in 1859 that all species are appearing through a process of evolution, adaptation and selection. There is no determined origin to any animal or plant species, simply an evolutionary and selective process in which chance and environment play a key role. The very same is true for viruses. There is no determined origin to viruses, simply also an evolutionary and selective process in which chance and environment play a key role. However, in the case of viruses the process is slightly more complex because the environment is another living organism. Pandemic viruses already circulate in humans prior to the emergence of a disease. They are simply not capable of triggering an epidemic yet. They must evolve in-host, i.e. in-humans, for that. The evolutionary process which gave rise to SARS-CoV-2 is still ongoing with regular emergence of novel variants more adapted than the previous ones. The real relevant question is how these viruses can emerge as pandemic viruses and what the society can do to prevent the future emergence of pandemic viruses.

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