Journal
ENVIRONMENTAL POLLUTION
Volume 300, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2022.118986
Keywords
Micro-PS; Hepatotoxicity; DNA damage; Inflammation; Fibrosis
Categories
Funding
- National Natural Science Foundation of China [82071695, 82060535]
- Natural Science Foundation of Gansu Province [21JR7RA450]
- Innovation Fund of Higher Education of Gansu Province [2021B-010]
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This study provides valuable insights into the potential risk and mechanism of hepatic toxicity and fibrosis induced by microplastics. It demonstrates that even at low concentrations, microplastics can enter hepatocytes and cause liver damage. Microplastic exposure results in DNA damage and inflammation, leading to liver fibrosis. Moreover, inhibiting the relevant signaling pathway can alleviate liver fibrosis.
The environmental pollution from microplastics has caused concern from the whole society due to its harm to organisms. However, the effect of microplastics on liver damage and fibrosis remains unclear in the case of longterm accumulation. The present study demonstrated that the 0.1 mu m microplastic could enter hepatocytes from circulation and result liver damage even at a low concentration. Microplastic exposure could induce DNA damage in both nucleus and mitochondria, by which the dsDNA fragment was translocated into cytoplasm and triggered the DNA sensing adaptor STING. The activation of cGAS/STING pathway initiated the downstream cascade reaction, the NF kappa B translocated into nucleus and upregulated pro-inflammatory cytokines expression, and thus facilitating liver fibrosis eventually. Furthermore, inhibition of STING could alleviate the liver fibrosis via blocking the NF kappa B translocation and fibronectin expression. This study provided a valuable insight to elucidate the potential risk and mechanism of hepatic toxicity and fibrosis induced by microplastics.
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