4.2 Article

AOP report: Development of an adverse outcome pathway for oxidative DNA damage leading to mutations and chromosomal aberrations

Related references

Note: Only part of the references are listed.
Article Biology

A case example of a radiation-relevant adverse outcome pathway to lung cancer

Vinita Chauhan et al.

Summary: Adverse Outcome Pathways (AOPs) describe how a sequence of key events starting from a molecular initiator can lead to adverse outcomes relevant to risk assessment. This framework helps organize scientific knowledge, identify potential risks, and in this case study, understand the process of lung cancer induction.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2021)

Article Genetics & Heredity

CometChip enables parallel analysis of multiple DNA repair activities

Jing Ge et al.

Summary: DNA damage is directly linked to aging, cancer, and other diseases, and cells have evolved highly conserved DNA repair pathways to counteract its deleterious effects. The CometChip platform offers increased throughput and sensitivity for parallel analysis of multiple DNA repair activities, expanding the utility of the comet assay for precise, high-throughput assessment of repair deficiencies in different pathways.

DNA REPAIR (2021)

Article Biochemistry & Molecular Biology

CometChip analysis of human primary lymphocytes enables quantification of inter-individual differences in the kinetics of repair of oxidative DNA damage

Le P. Ngo et al.

Summary: By utilizing the CometChip, researchers uncovered significant variability in DNA repair efficiency among individuals, indicating its potential utility in future epidemiological and clinical studies.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Article Cell Biology

Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice

Jennifer E. Kay et al.

Summary: Research has shown that altering the levels of the DNA repair protein AAG can impact disease outcomes, switching from cancer to lethality. Specifically, unrepaired 3-methyladenine is somewhat toxic but highly mutagenic, promoting cancer, while excess DNA strand breaks are poorly mutagenic but highly toxic, suppressing cancer and promoting lethality. This highlights the importance of a single DNA repair protein in determining the disease consequences of DNA damage.

CELL REPORTS (2021)

Article Cell Biology

BRCA2 deficiency reveals that oxidative stress impairs RNaseH1 function to cripple mitochondrial DNA maintenance

Xavier Renaudin et al.

Summary: Oxidative stress is a common cellular challenge linked to mitochondrial DNA replication impairment. BRCA2 inactivation leads to R-loop accumulation in the mtDNA regulatory region and hinders mtDNA replication initiation. The impairment of RNaseH1 recruitment by oxidative stress restricts mtDNA maintenance and highlights a molecular link between oxidative stress and mitochondrial dysfunction.

CELL REPORTS (2021)

Article Environmental Sciences

Application of the adverse outcome pathway framework to genotoxic modes of action

Jennifer C. Sasaki et al.

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2020)

Article Environmental Sciences

Next-Generation Genotoxicology: Using Modern Sequencing Technologies to Assess Somatic Mutagenesis and Cancer Risk

Jesse J. Salk et al.

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2020)

Editorial Material Environmental Sciences

Mutation as a Toxicological Endpoint for Regulatory Decision-Making

Robert H. Heflich et al.

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2020)

Article Biochemistry & Molecular Biology

A Genetic Map of the Response to DNA Damage in Human Cells

Michele Olivieri et al.

Article Genetics & Heredity

Synergic toxic effects of food contaminant mixtures in human cells

Benjamin Kopp et al.

MUTAGENESIS (2020)

Article Genetics & Heredity

The mutational signature profile of known and suspected human carcinogens in mice

Laura Riva et al.

NATURE GENETICS (2020)

Article Environmental Sciences

Predictions of genotoxic potential, mode of action, molecular targets, and potency via a tiered multiflow® assay data analysis strategy

Stephen D. Dertinger et al.

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2019)

Review Environmental Sciences

Key characteristics of 86 agents known to cause cancer in humans

Daniel Krewski et al.

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS (2019)

Review Genetics & Heredity

Searching for assay controls for the Fpg- and hOGG1-modified comet assay

Peter Moller et al.

MUTAGENESIS (2018)

Article Genetics & Heredity

Nitric oxide induced S-nitrosation causes base excision repair imbalance

Marcus C. Parrish et al.

DNA REPAIR (2018)

Review Biotechnology & Applied Microbiology

Microhomology-mediated end joining: Good, bad and ugly

Ja-Hwan Seol et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2018)

Review Genetics & Heredity

Break-Induced Replication: The Where, The Why, and The How

J. Kramara et al.

TRENDS IN GENETICS (2018)

Article Cell Biology

Detection of DNA double-strand breaks by pulsed-field gel electrophoresis

Yuri Kawashima et al.

GENES TO CELLS (2017)

Review Biochemistry & Molecular Biology

Repair of 8-oxoG: A mismatches by the MUTYH glycosylase: Mechanism, metals and medicine

Douglas M. Banda et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Review Biochemistry & Molecular Biology

Formation and repair of oxidatively generated damage in cellular DNA

Jean Cadet et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Review Biochemistry & Molecular Biology

DNA damage related crosstalk between the nucleus and mitochondria

Mohammad Saki et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Article Biochemistry & Molecular Biology

Base excision repair of oxidative DNA damage: from mechanism to disease

Amy M. Whitaker et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2017)

Review Cell Biology

Non-homologous DNA end joining and alternative pathways to double-strand break repair

Howard H. Y. Chang et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

Article Biochemistry & Molecular Biology

Abasic and oxidized ribonucleotides embedded in DNA are processed by human APE1 and not by RNase H2

Matilde Clarissa Malfatti et al.

NUCLEIC ACIDS RESEARCH (2017)

Article Multidisciplinary Sciences

Development and validation of a high-throughput transcriptomic biomarker to address 21st century genetic toxicology needs

Heng-Hong Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Biology

N-Acetyl-L-cysteine protects thyroid cells against DNA damage induced by external and internal irradiation

Tomomi Kurashige et al.

RADIATION AND ENVIRONMENTAL BIOPHYSICS (2017)

Article Multidisciplinary Sciences

Oxidized nucleotide insertion by pol β confounds ligation during base excision repair

Melike Caglayan et al.

NATURE COMMUNICATIONS (2017)

Review Genetics & Heredity

Not breathing is not an option: How to deal with oxidative DNA damage

Enni Markkanen

DNA REPAIR (2017)

Review Environmental Sciences

Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis

Martyn T. Smith et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2016)

Review Cell Biology

Mechanisms and Consequences of Double-Strand DNA Break Formation in Chromatin

Wendy J. Cannan et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2016)

Review Cell Biology

Error-Prone Repair of DNA Double-Strand Breaks

Kasey Rodgers et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2016)

Editorial Material Cell Biology

Keeping homologous recombination in check

Kasper Fugger et al.

CELL RESEARCH (2016)

Article Environmental Sciences

Genotoxic mode of action predictions from a multiplexed flow cytometric assay and a machine learning approach

Steven M. Bryce et al.

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2016)

Article Biochemistry & Molecular Biology

Base and Nucleotide Excision Repair of Oxidatively Generated Guanine Lesions in DNA

Vladimir Shafirovich et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Review Cell Biology

ROS homeostasis and metabolism: a dangerous liason in cancer cells

E. Panieri et al.

CELL DEATH & DISEASE (2016)

Article Multidisciplinary Sciences

Catalysts of DNA Strand Cleavage at Apurinic/Apyrimidinic Sites

Irina G. Minko et al.

SCIENTIFIC REPORTS (2016)

Article Environmental Sciences

Cadmium Chloride Induces DNA Damage and Apoptosis of Human Liver Carcinoma Cells via Oxidative Stress

Anthony Skipper et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2016)

Article Multidisciplinary Sciences

Mechanistic Modelling of DNA Repair and Cellular Survival Following Radiation-Induced DNA Damage

Stephen J. McMahon et al.

SCIENTIFIC REPORTS (2016)

Article Critical Care Medicine

Increased Mutagen Sensitivity and DNA Damage in Pulmonary Arterial Hypertension

Chiara Federici et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2015)

Article Biotechnology & Applied Microbiology

DNA damage in neurodegenerative diseases

Fabio Coppede et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2015)

Article Biotechnology & Applied Microbiology

The in vivo Pig-a assay: A report of the International Workshop On Genotoxicity Testing (IWGT) Workgroup

B. Bhaskar Gollapudi et al.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2015)

Article Biotechnology & Applied Microbiology

Construction of a cytogenetic dose-response curve for low-dose range gamma-irradiation in human peripheral blood lymphocytes using three-color FISH

Yumiko Suto et al.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2015)

Review Biochemistry & Molecular Biology

Biological Activities of Reactive Oxygen and Nitrogen Species: Oxidative Stress versus Signal Transduction

Adelheid Weidinger et al.

BIOMOLECULES (2015)

Review Biochemistry & Molecular Biology

The role of mitochondrial DNA mutation on neurodegenerative diseases

Moon-Yong Cha et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2015)

Review Chemistry, Multidisciplinary

Abasic and Oxidized Abasic Site Reactivity in DNA: Enzyme Inhibition, Cross-Linking, and Nucleosome Catalyzed Reactions

Marc M. Greenberg

ACCOUNTS OF CHEMICAL RESEARCH (2014)

Review Biochemistry & Molecular Biology

Repair of Oxidative DNA Damage and Cancer: Recent Progress in DNA Base Excision Repair

Timothy L. Scott et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

Review Oncology

Base excision repair capacity in informing healthspan

Boris M. Brenerman et al.

CARCINOGENESIS (2014)

Article Chemistry, Medicinal

Mutagenic Potential of 8-Oxo-7,8-dihydro-2′-deoxyguanosine Bypass Catalyzed by Human Y-Family DNA Polymerases

David J. Taggart et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2014)

Review Cardiac & Cardiovascular Systems

Role of DNA Damage in Cardiovascular Disease

Takafumi Ishida et al.

CIRCULATION JOURNAL (2014)

Article Chemistry, Applied

Cytotoxicity and DNA damage properties of tert-butylhydroquinone (TBHQ) food additive

Morteza Eskandani et al.

FOOD CHEMISTRY (2014)

Article Cell Biology

DNA breaks and chromosomal aberrations arise when replication meets base excision repair

Michael Ensminger et al.

JOURNAL OF CELL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa

Leena Maddukuri et al.

NUCLEIC ACIDS RESEARCH (2014)

Article Toxicology

Adverse Outcome Pathway (AOP) Development I: Strategies and Principles

Daniel L. Villeneuve et al.

TOXICOLOGICAL SCIENCES (2014)

Review Biochemistry & Molecular Biology

Oxidative Stress and the DNA Mismatch Repair Pathway

David J. Brierley et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Review Biochemistry & Molecular Biology

Oxidative DNA Damage and Nucleotide Excision Repair

Joost P. M. Melis et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Article Environmental Sciences

ACB-PCR Measurement of Spontaneous and Furan-Induced H-ras Codon 61 CAA to CTA and CAA to AAA Mutation in B6C3F1 Mouse Liver

Malathi Banda et al.

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2013)

Article Environmental Sciences

Validation of High-Throughput Genotoxicity Assay Screening Using γH2AX In-Cell Western Assay on HepG2 Cells

Laure Khoury et al.

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2013)

Article Biotechnology & Applied Microbiology

Assessment of the in vitro γH2AX assay by High Content Screening as a novel genotoxicity test

Carolina Garcia-Canton et al.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2013)

Article Biochemistry & Molecular Biology

Replication fork collapse is a major cause of the high mutation frequency at three-base lesion clusters

Yuliya Sedletska et al.

NUCLEIC ACIDS RESEARCH (2013)

Article Multidisciplinary Sciences

Germ-line variant of human NTH1 DNA glycosylase induces genomic instability and cellular transformation

Heather A. Galick et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Cell Biology

DNA Base Damage by Reactive Oxygen Species, Oxidizing Agents, and UV Radiation

Jean Cadet et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)

Review Oncology

Pathways for repairing and tolerating the spectrum of oxidative DNA lesions

Brian R. Berquist et al.

CANCER LETTERS (2012)

Review Biochemistry & Molecular Biology

DNA glycosylases: in DNA repair and beyond

Angelika L. Jacobs et al.

CHROMOSOMA (2012)

Article Cell Biology

Replication stress and mechanisms of CNV formation

Martin F. Arlt et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2012)

Review Biochemistry & Molecular Biology

Formation of ring-opened and rearranged products of guanine: Mechanisms and biological significance

N. R. Jena et al.

FREE RADICAL BIOLOGY AND MEDICINE (2012)

Review Biotechnology & Applied Microbiology

Role of Nitrative and Oxidative DNA Damage in Inflammation-Related Carcinogenesis

Mariko Murata et al.

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2012)

Article Medicine, Research & Experimental

8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair

Zijing Sheng et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Article Multidisciplinary Sciences

Homologous chromosomes make contact at the sites of double-strand breaks in genes in somatic G0/G1-phase human cells

Manoj Gandhi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Review Cell Biology

Signal transduction by reactive oxygen species

Toren Finkel

JOURNAL OF CELL BIOLOGY (2011)

Article Medicine, Research & Experimental

Oxidative damage DNA: 8-oxoGua and 8-oxodG as molecular markers of cancer

Krzysztof Roszkowski et al.

MEDICAL SCIENCE MONITOR (2011)

Article Multidisciplinary Sciences

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

Zhiyong Mao et al.

SCIENCE (2011)

Article Environmental Sciences

ADVERSE OUTCOME PATHWAYS: A CONCEPTUAL FRAMEWORK TO SUPPORT ECOTOXICOLOGY RESEARCH AND RISK ASSESSMENT

Gerald T. Ankley et al.

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2010)

Review Biochemistry & Molecular Biology

Reactive oxygen species in cancer

Geou-Yarh Liou et al.

FREE RADICAL RESEARCH (2010)

Article Biotechnology & Applied Microbiology

Study of oxidative DNA damage in TK6 human lymphoblastoid cells by use of the in vitro micronucleus test: Determination of No-Observed-Effect Levels

Anne Platel et al.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2009)

Article Biochemistry & Molecular Biology

Processing of thymine glycol in a clustered DNA damage site: mutagenic or cytotoxic

Sophie Bellon et al.

NUCLEIC ACIDS RESEARCH (2009)

Article Environmental Sciences

Potassium Dichromate Induced Cytotoxicity, Genotoxicity and Oxidative Stress in Human Liver Carcinoma (HepG2) Cells

Anita K. Patlolla et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2009)

Article Public, Environmental & Occupational Health

Formation of 8-nitroguanine, a nitrative DNA lesion, in inflammation-related carcinogenesis and its significance

Yusuke Hiraku

Environmental Health and Preventive Medicine (2009)

Review Oncology

Measurement and meaning of oxidatively modified DNA lesions in urine

Marcus S. Cooke et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2008)

Review Cell Biology

ROS as signalling molecules:: mechanisms that generate specificity in ROS homeostasis

Benoit D'Autreaux et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Repair of formamidopyrimidines in DNA involves different glycosylases - Role of the OGG1, NTH1, and NEIL1 enzymes

JP Hu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Chemistry, Medicinal

Quantitation of four guanine oxidation products from reaction of DNA with varying doses of peroxynitrite

HB Yu et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2005)

Article Biochemistry & Molecular Biology

Chemical and biological evidence for base propenals as the major source of the endogenous M1dG adduct in cellular DNA

XF Zhou et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Review Biochemistry & Molecular Biology

The comet assay for DNA damage and repair - Principles, applications, and limitations

AR Collins

MOLECULAR BIOTECHNOLOGY (2004)

Article Biochemistry & Molecular Biology

Imbalanced base excision repair in response to folate deficiency is accelerated by polymerase β haploinsufficiency

DC Cabelof et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Cell Biology

Mechanisms of DNA double strand break repair and chromosome aberration formation

G Iliakis et al.

CYTOGENETIC AND GENOME RESEARCH (2004)

Article Biochemistry & Molecular Biology

Enhanced mutagenic potential of 8-oxo-7,8-dihydroguanine when present within a clustered DNA damage site

CG Pearson et al.

NUCLEIC ACIDS RESEARCH (2004)

Article Biochemistry & Molecular Biology

Futile short-patch DNA base excision repair of adenine : 8-oxoguanine mispair

K Hashimoto et al.

NUCLEIC ACIDS RESEARCH (2004)

Review Biochemistry & Molecular Biology

Oxidative DNA damage: mechanisms, mutation, and disease

MS Cooke et al.

FASEB JOURNAL (2003)

Article Oncology

Mutagen sensitivity of human lymphoblastoid cells with a BRCA1 mutation

K Trenz et al.

BREAST CANCER RESEARCH AND TREATMENT (2003)

Article Biochemistry & Molecular Biology

The mammalian mismatch repair pathway removes DNA 8-oxodGMP incorporated from the oxidized dNTP pool

C Colussi et al.

CURRENT BIOLOGY (2002)

Article Biochemistry & Molecular Biology

DNA double strand break repair and chromosomal translocation: Lessons from animal models

DO Ferguson et al.

ONCOGENE (2001)

Article Multidisciplinary Sciences

Single-strand interruptions in replicating chromosomes cause double-strand breaks

A Kuzminov

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Multidisciplinary Sciences

Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice

O Minowa et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

Article Biochemistry & Molecular Biology

Comparison of different methods of measuring 8-oxoguanine as a marker of oxidative DNA damage

AR Collins et al.

FREE RADICAL RESEARCH (2000)