Journal
EMBO MOLECULAR MEDICINE
Volume 14, Issue 5, Pages -Publisher
WILEY
DOI: 10.15252/emmm.202114742
Keywords
enterocyte; fat absorption; intestine; metabolic diseases; triglycerides
Categories
Funding
- Dioscuri Centre of Scientific Excellence-a program by the Max Planck Society
- Polish Ministry of Science and Higher Education
- German Federal Ministry of Education and Research
- National Science Centre, Poland [2020/38/E/NZ4/00314]
- European Molecular Biology Organization (EMBO)
- German Research Foundation [DFG-CRC 1371: P13, HA 8213/3-1]
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Overconsumption of energy-dense foods can lead to increased intestinal nutrient absorption and excessive lipid accumulation, resulting in obesity and obesity-associated diseases. Targeting the pathways that regulate intestinal nutrient absorption holds significant therapeutic potential.
The regular overconsumption of energy-dense foods (rich in lipids and sugars) results in elevated intestinal nutrient absorption and consequently excessive accumulation of lipids in the liver, adipose tissue, skeletal muscles, and other organs. This can eventually lead to obesity and obesity-associated diseases such as type 2 diabetes (T2D), non-alcoholic fatty liver disease (NAFLD), cardiovascular disease, and certain types of cancer, as well as aggravate inflammatory bowel disease (IBD). Therefore, targeting the pathways that regulate intestinal nutrient absorption holds significant therapeutic potential. In this review, we discuss the molecular and cellular mechanisms controlling intestinal lipid handling, their relevance to the development of metabolic diseases, and emerging therapeutic strategies.
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