Hyperphosphorylation tunes TDP-43 solubility

Post-translational modifications of intrinsically disordered regions (IDRs) enable changes in sequence chemistry, which in turn can tune conformational behavior and molecular interactions. In this issue of The EMBO Journal, Gruijs da Silva et al disentangle the effect of hyperphosphorylation on the C-terminal domain of TDP-43, a key IDR implicated in Amyotrophic Lateral Sclerosis (ALS).

Automated summary

This article investigates the impact of phosphorylation modification on the C-terminal domain of TDP-43, a protein implicated in Amyotrophic Lateral Sclerosis (ALS).