The goodies of chelated fat: iron-regulated lipid droplet biogenesis precedes and preserves mitophagy

The role of iron-regulated mitophagy in lipid metabolism is unclear. Recent work by Long, Sanchez-Martinez et al (2022) shows that iron chelation induces a primary change in lipid metabolism that promotes fat accumulation and precedes mitophagy.

Automated summary

The study demonstrates that iron chelation triggers a primary change in lipid metabolism, resulting in fat accumulation before mitophagy.