4.7 Article

FoxO-promoted peroxiredoxin1 expression induced by Helicoverpa armigera single nucleopolyhedrovirus infection mediates host development and defensive responses

Journal

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Volume 234, Issue -, Pages -

Publisher

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2022.113414

Keywords

Development; Forkhead box O; Host immunity; Oxidative stress; Reactive oxygen species

Funding

  1. National Natural Science Foundation of China [31972275]

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Infection of Helicoverpa armigera single nucleopolyhedrovirus (HearNPV) can restrict the growth and development of larvae by inducing reactive oxygen species (ROS) and affecting immune responses. The transcription factor forkhead box O (FoxO) upregulates the expression of peroxiredoxin 1 (Prx1), which plays a role in regulating larval development and immunity following HearNPV infection.
Helicoverpa armigera single nucleopolyhedrovirus (HearNPV) has a long coevolutionary history with its host, exerting profound effects on larval development, physiology and immune responses, although the mechanisms mediating these effects remain unclear. We demonstrate that HearNPV infection constrains the growth and development of larvae by inducing high levels of reactive oxygen species (ROS), which increase the expression of forkhead box O transcription factor (FoxO). FoxO upregulates the expression of peroxiredoxin 1 (Prx1) which serves to regulate larval development and immune responses following HearNPV infection. Collectively, our results provide novel insights into the role of Prx1 in larval development and immunity subsequent to HearNPV infection. Further investigation of the oxidative stress induced by HearNPV in H. armigera and its interactions with host immunity could yield novel insights useful in agricultural pest control.

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