Journal
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Volume 236, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2022.113481
Keywords
Aflatoxin B; Phillygenin; Liver; Antioxidative; Anti-inflammatory; Apoptosis
Categories
Funding
- National Project for Standardization of Chinese Materia Medica [ZYBZH-Y-JIN-34]
- Shanxi Provincial Key Research and Development Project [201603D3114015]
- Collabo-rative Innovation Center of Astragali Radix Resource Industrialization and Industrial Internationalization of Shanxi University of Chinese Medicine [HQXTCXZX2016-012]
- National Natural Science Foun-dation of China [U1812403]
- Guizhou Provincial Science and Technology Foundation [QKHRZ 2016-4018, QKHPTRZ 2019-5702]
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This research aimed to investigate the preventive effects of Phillygenin (PHI) on the toxicity of Aflatoxin B-1 (AFB(1)) in the liver of chickens. Results revealed that dietary PHI ameliorated liver function indicators, reduced oxidative damage and inflammatory response, decreased apoptosis, and increased antioxidant enzyme contents by inhibiting NF-kappa B and activating the Nrf2 signaling pathway. This study provides new insight into the therapeutic uses of PHI.
Aflatoxin B-1 (AFB(1)), a mycotoxin contaminating food and feed, can trigger liver immune toxicity and threaten the poultry industry. Phillygenin (PHI) is a natural lignan derived primarily from Forsythia suspensa with hepatoprotective pharmacological and medicinal properties. This research aimed to investigate the preventive effects of PHI on the toxicity of AFB(1) in the liver of chickens. Chickens were administered with AFB(1) (2.8 mg/kg) and/or treated with PHI (24 mg/kg) for 33 days. The histopathological changes, serum biochemical indices, oxidative damage, inflammatory mediators, apoptosis, and activation of the NF-kappa B and Nrf2 signaling pathways were measured. Results revealed that dietary PHI ameliorated liver function indicators, reduced the malon-dialdehyde and inflammatory mediator production and the apoptotic cell number, and increased the antioxidant enzyme contents and Bcl-2 level. The quantitative realtime PCR and Western blot results revealed that PHI reduced p53, cytochrome c, Bax, caspase-9, and caspase-3 levels, normalized the NF-kappa B p65 phosphorylation, and upregulated the Nrf2 and its downstream genes expression in chicken liver. These results indicated that PHI has beneficial effects on AFB(1)-induced liver damage, oxidative damage, inflammatory response, apoptosis, and immunotoxicity by inhibiting NF-kappa B and activating the Nrf2 signaling pathway in chickens. This study provides new insight into the therapeutic uses of PHI.
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