Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 84, Issue -, Pages 257-277Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2014.11.022
Keywords
Human and equine tendon injury; Tendon cellular and extracellular composition; Tendon healing; Tissue grafts; Biomaterials; Sustained and localised delivery of therapeutics/biologics
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Funding
- EU [251385, 263289]
- Science Foundation Ireland [SFI_09-RFP-ENM2483]
- Health Research Board, Health Research Awards Programme [HRA_POR/2011/84]
- Enterprise Ireland, Collaborative Centre for Applied Nanotechnology, under the Irish Government [CCIRP-2007-CCAN-0509]
- Teagasc, Department of Agriculture, Food and Marine, FIRM/RSF/CoFORD [11-F-043]
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Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent especially among young individuals with long life ahead of them. Advancements in engineering, chemistry and biology have made available an array of three-dimensional scaffold-based intervention strategies, natural or synthetic in origin. Further, functionalisation strategies, based on biophysical, biochemical and biological cues, offer control over cellular functions; localisation and sustained release of therapeutics/biologics; and the ability to positively interact with the host to promote repair and regeneration. Herein, we critically discuss current therapies and emerging technologies that aim to transform tendon treatments in the years to come. (C) 2014 Elsevier B.V. All rights reserved.
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