Journal
DYES AND PIGMENTS
Volume 199, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2022.110091
Keywords
Natural compounds modification; 4 '-methoxychalcone; Aggregation-induced emission; Lysosomal imaging
Funding
- National Natural Science Foundation of China [21975020, 21975021, 21875019, 51803009, 51673024]
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Three types of 4'-methoxychalcone derivatives were synthesized and studied, and it was found that the presence of a hydroxyl group at the 2-position of the A ring and strong electron-donating groups at the 4-position of the B ring were favorable for the fluorescence properties of the compounds. Different chalcone fluorophores with varying fluorescence properties could be obtained by modulating substituents at the 2-position of the A ring.
Three types of 4'-methoxychalcone derivatives Cha-1 similar to Cha-9 with different electron-withdrawing or electron-donating substituents at different positions were synthesized and studied. When the A ring has a hydroxyl group at the 2-position, the strong electron-donating groups at the 4-position of the B ring was more conducive to the near-infrared and aggregation-enhanced emission (AEE) features of the compound than the electron withdrawing groups. The single-crystal analysis confirmed that the good planarity of the 4' -methoxychalcone derivatives favors their fluorescence quantum yields. Moreover, chalcone fluorophores with different fluorescence properties could be obtained by modulating substituent at the 2-position of A ring. In addition, Cha-9 was selected as the AEE luminogen to locate the lysosomes in HeLa cells. These results provided fundamental knowledge for the design and application of 4'-methoxychalcone derivatives of aggregation-induced emission (AIE) compounds.
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