Journal
DRUG DISCOVERY TODAY
Volume 27, Issue 6, Pages 1774-1783Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2022.03.015
Keywords
Antibiotics; Antimicrobial resistance; Bacterial metabolism; Metabolomics
Categories
Ask authors/readers for more resources
This review explores the relationship between bacterial metabolism and antimicrobial resistance mechanisms, highlighting the potential for targeted interventions to sensitize resistant pathogens to antibiotic treatments through understanding and manipulating metabolic processes.
The emergence of antimicrobial resistance (AMR) in bacterial pathogens represents a global health threat. The metabolic state of bacteria is associated with a range of genetic and phenotypic resistance mechanisms. This review provides an overview of the roles of metabolic processes that are associated with AMR mechanisms, including energy production, cell wall synthesis, cell-cell communication, and bacterial growth. These metabolic processes can be targeted with the aim of re-sensitizing resistant pathogens to antibiotic treatments. We discuss how state-of-the-art metabolomics approaches can be used for comprehensive analysis of microbial AMR-related metabolism, which may facilitate the discovery of novel drug targets and treatment strategies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available