Journal
DRUG AND CHEMICAL TOXICOLOGY
Volume 46, Issue 2, Pages 392-399Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/01480545.2022.2042014
Keywords
Pterostilbene; anti-cancer reagent; subacute oral toxicology; toxicokinetics; preclinical study
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This study evaluated the subacute toxicity and toxicokinetics of a potential anti-cancer drug candidate, pterostilbene, in rats. The results showed that pterostilbene had minimal subacute toxicity, and its systemic exposure appeared to be linear within the tested dose range. These findings strongly support further development of pterostilbene as a novel anti-cancer agent.
This study evaluated the subacute toxicity and toxicokinetics of a potential anti-cancer drug candidate, pterostilbene, in rats. Animals were orally administered at two repeated doses of 200 and 500 mg/kg for 28 days. No mortality was observed during the 28 days of continuous administration of pterostilbene. Body weight and food consumption in each group increased steadily, while no significant difference was found. Liver weight in the 500 mg/kg female, but not male group increased with mild cytoplasmic vacuoles observed in histopathological study. Toxicokinetics was assessed by measuring plasma concentrations of pterostilbene on the first and 28th day of administration using UPLC-MS/MS. Toxicokinetic parameters showed that AUC(0-)(t) significantly increased in all animals, while the increase in females was greater than males. System exposure of pterostilbene appeared to be linear within the administrated dose range. In conclusion, our findings suggested a minimal subacute toxicity profile of pterostilbene, which could strongly support further development of this compound as a novel anti-cancer agent.
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