4.3 Article

Paradoxical role of the major DNA repair protein, OGG1, in action-at-a-distance mutation induction by 8-oxo-7,8-dihydroguanine

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

NEIL1 and NEIL2 Are Recruited as Potential Backup for OGG1 upon OGG1 Depletion or Inhibition by TH5487

Bishoy M. F. Hanna et al.

Summary: DNA damage caused by reactive oxygen species can lead to genetic mutations or cell death, and base excision repair is a major pathway for repairing such damage. This study demonstrates that NEIL1 and NEIL2 can potentially serve as backup BER enzymes for OGG1 in the presence of pharmacological inhibition or depletion of OGG1, indicating a prospective compensatory role for NEIL1 and NEIL2 in maintaining genomic integrity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Genetics & Heredity

Action-at-a-distance mutations at 5′-GpA-3′ sites induced by oxidised guanine in WRN-knockdown cells

Tetsuya Suzuki et al.

Summary: In human cells, G:C sites distant from 8-oxo-7,8-dihydroguanine are frequently mutated when the Werner syndrome (WRN) protein is reduced. The study suggests the involvement of APOBEC3-family cytosine deaminases in untargeted mutations at G:C sites induced by G degrees and in cancer initiation by oxidative stress.

MUTAGENESIS (2021)

Article Toxicology

Similar frequency and signature of untargeted substitutions induced by abasic site analog under reduced human APE1 conditions

Tetsuya Suzuki et al.

Summary: Studies have shown that abasic sites formed in cells may be involved in cancer, but mutations caused by certain abasic site analogs may not necessarily be affected by human apurinic/apyrimidinic endonuclease 1.

JOURNAL OF TOXICOLOGICAL SCIENCES (2021)

Editorial Material Genetics & Heredity

High-throughput analysis of DNA repair in microplates towards identification of inhibitors

Hiroyuki Kamiya

GENES AND ENVIRONMENT (2020)

Article Genetics & Heredity

New indicator Escherichia coli strain for rapid and accurate detection of supF mutations

Ruriko Fukushima et al.

GENES AND ENVIRONMENT (2020)

Article Chemistry, Medicinal

Action-at-a-Distance Mutagenesis Induced by Oxidized Guanine in Werner Syndrome Protein-Reduced Human Cells

Hiroyuki Kamiya et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2015)

Article Oncology

Erroneous identification of APOBEC3-edited chromosomal DNA in cancer genomics

R. Suspene et al.

BRITISH JOURNAL OF CANCER (2014)

Article Multidisciplinary Sciences

Signatures of mutational processes in human cancer

Ludmil B. Alexandrov et al.

NATURE (2013)

Article Biochemical Research Methods

NIH Image to ImageJ: 25 years of image analysis

Caroline A. Schneider et al.

NATURE METHODS (2012)

Article Biochemistry & Molecular Biology

Non-B DNA-forming Sequences and WRN Deficiency Independently Increase the Frequency of Base Substitution in Human Cells

Albino Bacolla et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biotechnology & Applied Microbiology

Roles of specialized DNA polymerases in mutagenesis by 8-hydroxyguanine in human cells

Hiroyuki Kamiya et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2010)

Article Biochemistry & Molecular Biology

Mutagenic effects of 8-hydroxy-dGTP in live mammalian cells

Kazuya Satou et al.

FREE RADICAL BIOLOGY AND MEDICINE (2007)

Review Genetics & Heredity

Repair and genetic consequences of endogenous DNA base damage in mammalian cells

DE Barnes et al.

ANNUAL REVIEW OF GENETICS (2004)

Review Biotechnology & Applied Microbiology

The contribution of endogenous sources of DNA damage to the multiple mutations in cancer

AL Jackson et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2001)

Article Multidisciplinary Sciences

One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products

KA Datsenko et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)