Investigating local and systemic intestinal signalling in health and disease with Drosophila

Wholeoody health relies on complex inter-organ signalling networks that enable organisms to adapt to environmental perturbations and to changes in tissue homeostasis. The intestine plays a major role as a signalling centre by producing local and systemic signals that are relayed to the body and that maintain intestinal and organismal homeostasis. Consequently, disruption of intestinal homeostasis and signalling are associated with systemic diseases and multi-organ dysfunction. In recent years, the fruit fly Drosophila melanogaster has emerged as a prime model organism to study tissue-intrinsic and systemic signalling networks of the adult intestine due to its genetic tractability and functional conservation with mammals. In this Review, we highlight Drosophila research that has contributed to our understanding of how the adult intestine interacts with its microenvironment and with distant organs. We discuss the implications of these findings for understanding intestinal and wholeoody pathophysiology, and how future Drosophila studies might advance our knowledge of the complex interplay between the intestine and the rest of the body in health and disease.

Automated summary

Whole body health relies on complex inter-organ signalling networks, with the intestine playing a major role as a signalling center. Research on fruit fly Drosophila melanogaster has contributed to our understanding of how the adult intestine interacts with its microenvironment and distant organs. These findings have important implications for understanding intestinal and whole body pathophysiology.