Journal
JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
Volume 17, Issue 6, Pages 493-523Publisher
SPRINGER
DOI: 10.1007/s10162-016-0589-1
Keywords
mice; inbred; outbred; recombinant inbred; knockout; cochlea; deafness; presbycusis; age-related hearing loss; noise-induced hearing loss; genetic hearing loss; hair cells; auditory neurons; lateral wall; stria vascularis; vestibular; vestibular testing; saccule; utricle; maculae; semicircular canal; ampullae
Categories
Funding
- Washington University Medical School Department of Otolaryngology
- Nebraska Tobacco Settlement Biomedical Research Foundation
- NIH NIDCD [RO1 DC004301, R01 DC005827]
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Laboratory mice (Mus musculus) have become the major model species for inner ear research. The major uses of mice include gene discovery, characterization, and confirmation. Every application of mice is founded on assumptions about what mice represent and how the information gained may be generalized. A host of successes support the continued use of mice to understand hearing and balance. Depending on the research question, however, some mouse models and research designs will be more appropriate than others. Here, we recount some of the history and successes of the use of mice in hearing and vestibular studies and offer guidelines to those considering how to apply mouse models.
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