Journal
DEVELOPMENTAL CELL
Volume 57, Issue 4, Pages 424-439Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2022.01.012
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Funding
- National Institutes of Health [K08 HL150335, HL151684, HL137710]
- American Heart Association Career Development Award
- Boston Children's Hospital Office of Faculty Development Career Development Award
- Harvard University Aramont Fellowship Fund for Emerging Science Research
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Cardiovascular disease is a major cause of death globally, and there is great interest in regenerative approaches for treating heart failure. In the past 20 years, there has been remarkable progress in the understanding of heart regeneration, stem cell differentiation, and cell-delivery methods. This review discusses how this new understanding can lead to viable strategies for human therapy.
Cardiovascular disease is a leading cause of death worldwide, and thus there remains great interest in regenerative approaches to treat heart failure. In the past 20 years, the field of heart regeneration has entered a renaissance period with remarkable progress in the understanding of endogenous heart regeneration, stem cell differentiation for exogenous cell therapy, and cell-delivery methods. In this review, we highlight how this new understanding can lead to viable strategies for human therapy. For the near term, drugs, electrical and mechanical devices, and heart transplantation will remain mainstays of cardiac therapies, but eventually regenerative therapies based on fundamental regenerative biology may offer more permanent solutions for patients with heart failure.
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