4.5 Review

Review of secukinumab-induced adverse events of special interest and its potential pathogenesis

Related references

Note: Only part of the references are listed.
Review Pharmacology & Pharmacy

Secukinumab for the treatment of psoriasis, psoriatic arthritis, and axial spondyloarthritis: Physical and pharmacological properties underlie the observed clinical efficacy and safety

Frank Kolbinger et al.

Summary: Psoriasis, psoriatic arthritis, and axial spondyloarthritis are systemic inflammatory diseases with varied symptoms and treatment responses. Secukinumab, a drug targeting IL-17A, has been used for over 6 years in the treatment of these diseases and has specific pharmacological properties.

PHARMACOLOGY & THERAPEUTICS (2022)

Review Rheumatology

IgA vasculitis during secukinumab therapy

Dijana Perkovic et al.

Summary: Psoriatic arthritis, a chronic seronegative spondyloarthropathy associated with psoriasis, is treated with various options ranging from non-pharmacologic measures to biologics. Secukinumab, a human monoclonal antibody targeting interleukin-17, has shown high effectiveness in treating this condition. However, clinicians should be aware of potential rare adverse events, such as Henoch-Schonlein purpura vasculitis, that may be induced by anti-IL17 treatment.

CLINICAL RHEUMATOLOGY (2021)

Editorial Material Rheumatology

Secukinumab-Induced Lupus Erythematosus A Case Report and Literature Review

Jaspreet Kaler et al.

JCR-JOURNAL OF CLINICAL RHEUMATOLOGY (2021)

Letter Rheumatology

Secukinumab-induced scleroderma: a case report

Nadia Elias et al.

RHEUMATOLOGY (2021)

Letter Dermatology

A systematic review of eczematous eruptions in patients receiving biologic therapy

Asfandyar Mufti et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2021)

Review Immunology

Current Insights and Future Prospects for Targeting IL-17 to Treat Patients With Systemic Lupus Erythematosus

Tomohiro Koga et al.

Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease with IL-17-producing cells playing a key role in its pathogenesis, making them a therapeutic target. Targeting IL-17 for treatment shows promising potential.

FRONTIERS IN IMMUNOLOGY (2021)

Review Immunology

The IL23-IL17 Immune Axis in the Treatment of Ulcerative Colitis: Successes, Defeats, and Ongoing Challenges

Daniele Noviello et al.

Summary: UC is a chronic relapsing disorder of the colonic tract, and the IL23/IL17 axis plays a key role in its pathogenesis. Blocking this pathway may offer a new approach for treating chronic inflammatory disorders, however, research on targeting the IL17 pathway is still ongoing.

FRONTIERS IN IMMUNOLOGY (2021)

Article Dermatology

Secukinumab-induced multiple lentigines in areas of resolved psoriatic plaques: A case report and literature review

Sanquan Zhang et al.

Summary: Psoriasis, a systemic inflammatory disease, can lead to changes in pigmentation, particularly in patients receiving anti-cytokine therapy. Close monitoring and management are essential in such cases.

DERMATOLOGIC THERAPY (2021)

Review Biochemistry & Molecular Biology

The Role of IL-17-Producing Cells in Cutaneous Fungal Infections

Yu Sawada et al.

Summary: The skin is exposed to various environmental stimuli, leading to inflammatory immune responses, especially towards cutaneous fungal infections. IL-17 producing cells play a crucial role in anti-fungal action, but their actual impact remains unclear. Research focuses on the role of IL-17-producing cells in cutaneous fungal infections and characteristics of infectious fungi on the skin.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Dermatology

Management of psoriasis as a systemic disease: what is the evidence?

N. J. Korman

BRITISH JOURNAL OF DERMATOLOGY (2020)

Editorial Material Rheumatology

Secukinumab-Induced Delayed-Type Drug Hypersensitivity Reactions

Sabrina Ching Tung Wong et al.

JCR-JOURNAL OF CLINICAL RHEUMATOLOGY (2020)

Letter Rheumatology

New onset of psoriasis induced by secukinumab in a patient with ankylosing spondylitis: a case report

D. Currado et al.

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY (2020)

Letter Dermatology

Secukinumab-induced paradoxical hidradenitis suppurativa

Francisco J. Navarro-Trivino et al.

DERMATOLOGIC THERAPY (2020)

Letter Pharmacology & Pharmacy

Secukinumab-Induced Acute Autoimmune Hemolytic Anemia

Rivas Sebastien et al.

ANNALS OF PHARMACOTHERAPY (2020)

Letter Dermatology

Pyoderma gangrenosum induced by secukinumab-A late paradoxical drug reaction

Uwe Wollina et al.

DERMATOLOGIC THERAPY (2020)

Letter Dermatology

Secukinumab-induced palmar vesiculopustular eruption in a patient with psoriasis

Masataka Satoh et al.

DERMATOLOGIC THERAPY (2020)

Letter Dermatology

Secukinumab-induced subacute cutaneous lupus erythematosus

Claudio Conforti et al.

DERMATOLOGIC THERAPY (2020)

Letter Pharmacology & Pharmacy

New-Onset Vitiligo During Treatment with Secukinumab: Report of Two Cases and Review of the Literature

Lula Maria Nieto-Benito et al.

CLINICAL DRUG INVESTIGATION (2020)

Article Medicine, General & Internal

New-Onset Uveitis Possibly Caused by Secukinumab in a 47-Year-Old Male Patient with Long-Standing Ankylosing Spondylitis

Huda Nadwi et al.

INTERNATIONAL MEDICAL CASE REPORTS JOURNAL (2020)

Article Pharmacology & Pharmacy

Secukinumab-induced Raynaud's phenomenon: first report in the literature

Senol Kobak

THERAPEUTIC ADVANCES IN DRUG SAFETY (2020)

Article Medicine, General & Internal

Dyshidrotic eczema in two patients on secukinumab for plaque psoriasis: A case report

Reetesh Bose et al.

SAGE OPEN MEDICAL CASE REPORTS (2020)

Letter Dermatology

Secukinumab-induced paradoxical pustular psoriasis

S. Dogra et al.

CLINICAL AND EXPERIMENTAL DERMATOLOGY (2019)

Letter Dermatology

Pyoderma gangrenosum triggered by switching from adalimumab to secukinumab

Kayo Jin et al.

JOURNAL OF DERMATOLOGY (2019)

Letter Dermatology

Pseudolymphoma induced by secukinumab for treatment of chronic plaque psoriasis

William C. Cranwell et al.

AUSTRALASIAN JOURNAL OF DERMATOLOGY (2019)

Review Immunology

The role of IL-17 in systemic lupus erythematosus and its potential as a therapeutic target

Tomohiro Koga et al.

EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2019)

Letter Dermatology

Eczematous eruption during anti-interleukin 17 treatment of psoriasis: an emerging condition

M. Napolitano et al.

BRITISH JOURNAL OF DERMATOLOGY (2019)

Review Gastroenterology & Hepatology

Systematic review and meta-analysis: risk of new onset IBD with the use of anti-interleukin-17 agents

Akihiro Yamada et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2019)

Letter Dermatology

Occurrence of Henoch-Schonlein purpura in a patient treated with secukinumab

M. Reverte et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2019)

Letter Dermatology

New onset alopecia areata during secukinumab therapy

Basak Yalici Armagan et al.

DERMATOLOGIC THERAPY (2019)

Article Ophthalmology

Secukinumab-Associated Crystalline Corneal Deposition

Barry Power et al.

CORNEA (2019)

Review Gastroenterology & Hepatology

IL-12, IL-23 and IL-17 in IBD: immunobiology and therapeutic targeting

Alexander R. Moschen et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

Article Medicine, General & Internal

Secukinumab induced Behcet's syndrome: a report of two cases

Elif Dincses et al.

OXFORD MEDICAL CASE REPORTS (2019)

Review Dermatology

Spotlight on brodalumab in the treatment of plaque psoriasis: the evidence to date

M. Galluzzo et al.

CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY (2019)

Article Dermatology

Secukinumab-induced subacute-cutaneous lupus erythematosus

C. Wehrmann et al.

HAUTARZT (2018)

Editorial Material Dermatology

IL-17C: A Unique Epithelial Cytokine with Potential for Targeting across the Spectrum of Atopic Dermatitis and Psoriasis

Emma Guttman-Yassky et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2018)

Editorial Material Dermatology

Eyelid Dermatitis as a Side Effect of Interleukin-17A Inhibitors in Psoriasis

Yuichi Teraki et al.

ACTA DERMATO-VENEREOLOGICA (2018)

Letter Dermatology

Paradoxical localized exacerbation of psoriatic eruptions triggered by secukinumab

D. Hoshina et al.

CLINICAL AND EXPERIMENTAL DERMATOLOGY (2018)

Article Dermatology

Neutralization of IL-17C Reduces Skin Inflammation in Mouse Models of Psoriasis and Atopic Dermatitis

Nick Vandeghinste et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2018)

Review Allergy

The Immunologic Role of IL-17 in Psoriasis and Psoriatic Arthritis Pathogenesis

Andrew Blauvelt et al.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2018)

Review Dermatology

Vasculitis-What Do We Have to Know? A Review of Literature

Eran Shavit et al.

INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS (2018)

Letter Dermatology

Recurrent angular cheilitis after secukinumab injections

Taiyo Hitaka et al.

AUSTRALASIAN JOURNAL OF DERMATOLOGY (2018)

Letter Dermatology

Oral lichen planus associated with candidiasis during secukinumab treatment

Takaya Komori et al.

JOURNAL OF DERMATOLOGY (2017)

Letter Gastroenterology & Hepatology

Interleukin-17A Inhibitor-induced Crohn's Disease/Behcet's Disease-like Lesions

Hisashi Shiga et al.

INFLAMMATORY BOWEL DISEASES (2017)

Letter Dermatology

Secukinumab-induced interstitial pneumonia in a patient with psoriasis vulgaris

Ikko Kajihara et al.

JOURNAL OF DERMATOLOGY (2017)

Letter Dermatology

Development of bullous pemphigoid during secukinumab treatment for psoriasis

Po-Han Ho et al.

JOURNAL OF DERMATOLOGY (2017)

Letter Dermatology

Secukinumab-Induced Psoriasiform Eruption

Michael J. Sladden et al.

JAMA DERMATOLOGY (2017)

Letter Endocrinology & Metabolism

Adiposity induced by interleukin-17A blockade

T. Nakamura et al.

DIABETES & METABOLISM (2017)

Letter Dermatology

Drug eruption caused by secukinumab

Mayu Shibata et al.

EUROPEAN JOURNAL OF DERMATOLOGY (2017)

Article Gastroenterology & Hepatology

A Randomized, Double-Blind, Placebo-Controlled Phase 2 Study of Brodalumab in Patients With Moderate-to-Severe Crohn's Disease

Stephan R. Targan et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2016)

Review Pharmacology & Pharmacy

Safety of secukinumab in the treatment of psoriasis

Andrew Blauvelt

EXPERT OPINION ON DRUG SAFETY (2016)

Letter Dermatology

Perianal Dermatophytosis During Secukinumab Therapy for Plaque Psoriasis

Olivia Leigh Quach et al.

JAMA DERMATOLOGY (2016)

Editorial Material Immunology

Gut-Busters: IL-17 Ain't Afraid of No IL-23

Natasha Whibley et al.

IMMUNITY (2015)

Article Medicine, General & Internal

Secukinumab in Plaque Psoriasis - Results of Two Phase 3 Trials

Richard G. Langley et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Biochemistry & Molecular Biology

Negative feedback on IL-23 exerted by IL-17A during pulmonary inflammation

Elin Silverpil et al.

INNATE IMMUNITY (2013)

Review Rheumatology

Th17 cells and IL-17 A-Focus on immunopathogenesis and immunotherapeutics

Wim B. van den Berg et al.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2013)

Review Biotechnology & Applied Microbiology

Correlations between Psoriasis and Inflammatory Bowel Diseases

Nevena Skroza et al.

BIOMED RESEARCH INTERNATIONAL (2013)

Article Medicine, General & Internal

Mutual Antagonism of T Cells Causing Psoriasis and Atopic Eczema

Stefanie Eyerich et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Review Rheumatology

IL-17 and the Th17 lineage in systemic lupus erythematosus

Lee Ann Garrett-Sinha et al.

CURRENT OPINION IN RHEUMATOLOGY (2008)

Article Gastroenterology & Hepatology

Claudins regulate the intestinal barrier in response to immune mediators

T Kinugasa et al.

GASTROENTEROLOGY (2000)