Journal
DERMATOLOGIC THERAPY
Volume 35, Issue 8, Pages -Publisher
WILEY-HINDAWI
DOI: 10.1111/dth.15599
Keywords
adverse events of special interest; drug-associated vasculitis; drug-induced lupus erythematosus; eczematous drug eruption; IL-17A; inflammatory bowel disease; psoriasis; Secukinumab
Categories
Funding
- Science and Technology Program of Guangzhou [201904010191, 202102080095]
- Medical Science and Technology Research Foundation of Guangdong Province [A2019464]
- Characteristic Clinic Project of Guangzhou Health Commission [2019TS68]
Ask authors/readers for more resources
Although secukinumab has shown high efficacy and safety in psoriasis and psoriatic arthritis, it can lead to adverse events of special interest (AESI) such as inflammatory bowel disease, eczematous drug eruption, drug-associated vasculitis, and drug-induced lupus erythematosus. Most of these AESI are mild to moderate and resolve after discontinuation of secukinumab.
Although secukinumab has demonstrated high efficacy and favorable safety in moderate-to-severe psoriasis and psoriatic arthritis, patients developing adverse events of special interest (AESI) were reported increasingly in real-world practice. A systematic literature search of the PubMed database was conducted to identify clinical studies or case reports on secukinumab-induced AESI. More than 1077 patients (aged 18-74 years) from 55 studies were reported to have 24 AESI 3 days to 96 weeks after secukinumab treatment. The four most common AESI was inflammatory bowel disease (n > 1000), eczematous drug eruption (n > 30), drug-associated vasculitis (n = 8), and drug-induced lupus erythematosus (n = 4). Most of these AESI were only mild to moderately severe and resolved after secukinumab discontinuation without or with symptomatic treatment. Secukinumab has the potential to develop a number of AESI by probably dysregulating the different expression of polar T-cell axes (Th1, Th2, Th17, Th22, and/or Treg) and driving various cytokines in some patients. Physicians should be aware of these AESI for timely diagnosis and proper treatment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available