Journal
CYTOTHERAPY
Volume 24, Issue 4, Pages 385-392Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jcyt.2021.09.011
Keywords
Hematopoietic Stem Cell Transplant; Immune Reconstitution; T cells
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This article reviews the importance of effective immune reconstitution after allogeneic transplantation and provides perspective on measurable and modifiable milestones of immune reconstitution, which are crucial for improving transplant outcomes.
Allogeneic stem cell transplantation is a potentially curative therapy for some malignant and non-malignant disease. There have been substantial advances since the approaches first introduced in the 1970s, and the development of approaches to transplant with HLA incompatible or alternative donors has improved access to transplant for those without a fully matched donor. However, success is still limited by morbidity and mortality from toxicity and imperfect disease control. Here we review our emerging understanding of how reconstitution of effective immunity after allogeneic transplant can protect from these events and improve outcomes. We provide perspective on milestones of immune reconstitution that are easily measured and modifiable. (C) 2021 International Society for Cell & Gene Therapy. Published by Elsevier Inc. All rights reserved.
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