Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 88, Issue -, Pages 123-137Publisher
ELSEVIER
DOI: 10.1016/j.addr.2014.12.006
Keywords
MiRNA; Anti-miR; MiRNA inhibition; Tissue engineering; Regenerative medicine
Categories
Funding
- National Science Foundation [DMR-120701, BMAT 1349604]
- National Institutes of Health ( NIBIB) [R21EB012750, R01 EB019409]
- Graduate Research Fellowship
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1207019] Funding Source: National Science Foundation
Ask authors/readers for more resources
MicroRNAs (miRNAs) are noncoding RNAs that provide an endogenous negative feedback mechanism for translation of messenger RNA (mRNA) into protein. Single miRNAs can regulate hundreds of mRNAs, enabling miRNAs to orchestrate robust biological responses by simultaneously impacting multiple gene networks. MiRNAs can act as master regulators of normal and pathological tissue development, homeostasis, and repair, which has motivated expanding efforts toward the development of technologies for therapeutically modulating miRNA activity for regenerative medicine and tissue engineering applications. This review highlights the tools currently available for miRNA inhibition and their recent therapeutic applications for improving tissue repair. (C) 2014 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
