Journal
CURRENT ORGANIC CHEMISTRY
Volume 26, Issue 5, Pages 427-431Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1385272826666220408105613
Keywords
Sparteine; chiral ligand; asymmetric synthesis; green chemistry; transition metal catalysis; cinchona alkaloids
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Funding
- NSFC [21871207, 21672159]
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This article reviews the use of Sparteine or its analogues as ligands in transition metal-involved asymmetric transformations and proposes further design and perspectives for similar ligands.
Chiral ligands are the footstones for asymmetric synthesis, constructing the enantio-enriched molecules that are widely used in material and medicinal sciences. Naturally occurring compounds, such as proline analogues and cinchona alkaloids, are widely used as privileged ligands in asymmetric synthesis. Sparteine, a natural alkaloid firstly reported in 1968, was also employed in asymmetric synthesis, albeit with less satisfactory results. In this perspective, transition metal-involved asymmetric transformations using sparteine or family members as ligands are overviewed and discussed. The design and perspective of ligands with similar skeleton are also proposed.
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