Structural insight into protein-protein interactions between intestinal microbiome and host

Protein-protein interactions between the microbiome and host organism play an important role in shaping host health. These host-modulating proteins have therapeutic potential in treating microbiome-linked disorders such as inflammatory bowel disease and obesity. Structural analysis of interacting proteins provides highly mechanistic insight into the domains driving these interactions and the resulting influence on host cell processes. Here, we briefly review recent publication of microbiome protein structures involved in host binding interactions, the effects of these interactions on host physiology, and the need for further study to increase the ability to detect proteins with therapeutic potential.

Automated summary

Protein-protein interactions between the microbiome and host organism play a crucial role in determining host health and have potential therapeutic applications. Structural analysis of these interactions provides valuable insights into the mechanisms and influence on host cell processes. Further research is needed to enhance the detection of proteins with therapeutic potential.