Journal
CURRENT OPINION IN PLANT BIOLOGY
Volume 67, Issue -, Pages -Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.pbi.2022.102222
Keywords
Omics; Metabolic pathway databases; Metabolic gene clusters; Novel pathway discovery
Categories
Funding
- U.S. Department of Energy, Office of Science, Office of Biological and Environmental Research, Genomic Science Program [DE-SC0018277, DE-SC0020366, DE-SC0021286]
- U.S. National Science Foundation [MCB-2052590, MCB-1916797, IOS-1546838]
- U.S. Department of Energy (DOE) [DE-SC0021286] Funding Source: U.S. Department of Energy (DOE)
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This review discusses plant enzyme and pathway annotation resources and cutting-edge omics approaches to guide the discovery and characterization of plant metabolic pathways. Currently, only a small fraction of the metabolic capacity possessed by plants is known, leaving a significant research gap.
Plants produce a vast array of metabolites, the biosynthetic routes of which remain largely undetermined. Genome-scale enzyme and pathway annotations and omics technologies have revolutionized research to decrypt plant metabolism and produced a growing list of functionally characterized metabolic genes and pathways. However, what is known is still a tiny fraction of the metabolic capacity harbored by plants. Here, we review plant enzyme and pathway annotation resources and cutting-edge omics approaches to guide discovery and characterization of plant metabolic pathways. We also discuss strategies for improving enzyme function prediction by integrating protein 3D structure information and single cell omics. This review aims to serve as a primer for plant biologists to leverage omics datasets to facilitate understanding and engineering plant metabolism.
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