4.7 Review

The metabolic homeostaTOR: The balance of holding on or letting grow

Journal

CURRENT OPINION IN PLANT BIOLOGY
Volume 66, Issue -, Pages -

Publisher

CURRENT BIOLOGY LTD
DOI: 10.1016/j.pbi.2022.102196

Keywords

TOR signalling; Plant growth; Metabolism; Metabolic homeostasis

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Funding

  1. Max Planck Society

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Plants capture light energy to convert carbon dioxide into essential substances for growth and development. The Target Of Rapamycin (TOR) signalling pathway plays a crucial role in sensing and regulating energy and nutrient availability. Recent research has highlighted the importance of this pathway in maintaining metabolic homeostasis and controlling growth and development across different tissues and organs in plants.
Plants, as autotrophic organisms, capture light energy to convert carbon dioxide into ATP, NADPH, and sugars, which are essential for the biosynthesis of building blocks, cell proliferation, biomass accumulation, and reproductive fitness. The Target Of Rapamycin (TOR) signalling pathway is a master regulator in sensing energy and nutrients, adapting the metabolic network and cell behaviour in response to environmental resource availability. In the past years, exciting advances in this endeavour have pointed out this pathway's importance in controlling metabolic homeostasis in various biological processes and systems. In this review, we discuss these recent discoveries highlighting the need for a metabolic threshold for the proper function of this kinase complex at the cellular level and across distinct tissues and organs to control growth and development in plants.

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