The true incidence of recurrent implantation failure

Purpose of review To review the merits and limitations of current definitions of recurrent implantation failure (RIF), how they translate into estimates of incidence and to summarize how emerging concepts of individualizing the recognition of this condition can assist in changing the way RIF is identified, studied and managed. Recent findings The notion of a one size fits all definition of RIF is seen to be of limited clinical value, as the individual risk of repeated IVF failure has many determinants and causes. Novel approaches provide a means of identifying 'actionable' RIF in individual patients. Uncertainties as to what constitutes, causes and defines RIF have served to limit progress in its management. A new approach promises to permit progress from the current impasse.

Automated summary

This review examines the current definitions of recurrent implantation failure (RIF) and their limitations, explores how these definitions impact the estimation of incidence, and summarizes the emerging concepts of personalized recognition of RIF and their potential to change the way it is identified, studied, and managed.