Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 66, Issue -, Pages 21-31Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2021.11.007
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Funding
- U.S. Department of Energy, Office of Science, Office of Biological and Environmental Research, Great Lakes Bioenergy Research Center [DE-SC0018409, DE-FC02-07ER64494]
- Center for Bioenergy Innovation (CBI) [DE-AC05-00OR22725, 4000158665]
- Early Career Research Program [DE-SC0018998]
- National Science Foundation (NSF) [1715710]
- U.S. Department of Energy (DOE) [DE-SC0018998] Funding Source: U.S. Department of Energy (DOE)
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1715710] Funding Source: National Science Foundation
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Thermodynamic analysis of metabolic networks is a valuable tool for pathway design and metabolic engineering, providing insights into the design principles of microbial carbon metabolism. This review summarizes the lessons learned from thermodynamic analysis, introduces computational thermodynamic tools, and highlights recent applications in industrially relevant microbes.
Thermodynamic analysis of metabolic networks has emerged as a useful new tool for pathway design and metabolic engineering. Understanding the relationship between the thermodynamic driving force of biochemical reactions and metabolic flux has generated new insights regarding the design principles of microbial carbon metabolism. This review summarizes the various lessons that can be obtained from the thermodynamic analysis of metabolic pathways, illustrates concepts of computational thermodynamic tools, and highlights recent applications of thermodynamic analysis to pathway design in industrially relevant microbes.
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