Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 66, Issue -, Pages -Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2021.11.012
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Funding
- Agence Nationale de la Recherche [ANR-13-JSV3-0005-01]
- Institut Universitaire de France
- CNRS-RFBR PRC 2019 [288426 19-54-15003]
- University Paris-Saclay, the Institute for Integrative Biology of the Cell, the DIM-1HEALTH regional Ile-de France program (LSP grant) [173403]
- Agence Nationale de la Recherche (ANR) [ANR-13-JSV3-0005] Funding Source: Agence Nationale de la Recherche (ANR)
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In this review, recent insights into the role of RNAs in modulating interactions between C. difficile and phages are discussed, along with intriguing data from other prokaryotes.
Clostridioides difficile (formerly Clostridium difficile)-associated diarrhea is currently the most frequently occurring nosocomial diarrhea worldwide. During its infection cycle this pathogen needs to survive in phage-rich gut communities. Recent data strongly suggest that regulatory RNAs control gene expression in C. difficile and many of these RNAs appear to modulate C. difficile-phage interactions. Of the 200 regulatory RNAs identified by deep sequencing and targeted approaches, many function as antitoxins within type I toxin-antitoxin modules and CRISPR RNAs for anti-phage defenses. In this review, we discuss recent insights into the role of RNAs in modulating interactions between C. difficile and phages in light of intriguing data in other prokaryotes.
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