Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 66, Issue -, Pages -Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2021.12.002
Keywords
-
Categories
Ask authors/readers for more resources
This article discusses the relationship between metabolic reprogramming and biofilm formation in Clostridioides difficile, as well as its overlap with the sporulation cascade. The findings provide important clues for modeling biofilm formation. However, further research is needed to answer outstanding questions in the field.
Clostridioides difficile is an opportunistic pathogen that causes by a high rate of recurrent infections. Persistence in the gastrointestinal tract is thought to be mediated by sporulation and/or biofilm formation. There is an increase interest in C. difficile biofilm formation and recent findings have provided a framework to model surface-attached biofilm formation. For in vitro biofilm formation, C. difficile must undergo a metabolic reprogramming as it enters stationary phase. This helps maintain long-term viability and increases responsiveness to signals leading to biofilm formation. Metabolic reprogramming and biofilm formation requires several regulatory factors and these overlap with the sporulation cascade. Despite recent advances, further research is needed to answer outstanding questions in the field.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available