☆ 4.2 Review

Heterogeneity and origins of myeloid cells

CURRENT OPINION IN HEMATOLOGY (2022)

Related references

Note: Only part of the references are listed.

Article Biochemistry & Molecular Biology

Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches

Martin Guilliams et al.

Summary: This study presents a spatial proteogenomic atlas of the liver, combining multiple omics datasets, and reveals the cellular niches and transcriptomic identities of Kupffer cells and lipid-associated macrophages. It also demonstrates the inducibility of lipid-associated macrophages by local lipid exposure and the crucial role of ALK1-BMP9/10 axis in Kupffer cell development.

CELL (2022)

Add to Collection

Article Immunology

CD127 imprints functional heterogeneity to diversify monocyte responses in inflammatory diseases

Bin Zhang et al.

Summary: Zhang et al. analyzed the functional heterogeneity of human monocytes in acute and chronic inflammatory disease conditions. They discovered a subset of CD127(+) hypoinflammatory monocytes within the inflammatory environment, suggesting the important role of CD127 in imprinting functional diversity in human monocytes. The study also found that CD127 marked a subset of monocytes/macrophages with hypoinflammatory phenotypes in COVID-19 and rheumatoid arthritis.

JOURNAL OF EXPERIMENTAL MEDICINE (2022)

Add to Collection

Article Multidisciplinary Sciences

Behavioural immune landscapes of inflammation

Georgiana Crainiciuc et al.

Summary: Transcriptional and proteomic profiling of individual cells have provided cellular landscapes of tissues, but fail to capture dynamic scenarios. This study used live imaging to record morpho-kinetic parameters of leukocytes in active inflammation and built behavioural landscapes that identified leukocyte identities and revealed a continuum of neutrophil states. Mutant screening identified the kinase Fgr as a driver of pathogenic inflammation, and interfering with Fgr protected mice from inflammatory injury.

NATURE (2022)

Add to Collection

Article Immunology

Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles

Sarah A. Dick et al.

Summary: This study reveals the existence of three macrophage subpopulations in mice based on common life cycle properties and core gene signatures. These subpopulations are present in multiple tissues and TLF+ macrophages show the highest transcriptional conservation.

SCIENCE IMMUNOLOGY (2022)

Add to Collection

Review Immunology

Trained Immunity: Reprogramming Innate Immunity in Health and Disease

Siroon Bekkering et al.

Summary: Trained immunity is a newly recognized phenomenon where cells of the innate immune system exhibit memory characteristics and enhanced responses upon secondary challenge. It explains the heterologous effects of vaccines, but can also lead to maladaptive effects in chronic inflammatory conditions.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 39 (2021)

Add to Collection

Review Cell Biology

Heterogeneity of Intestinal Tissue Eosinophils: Potential Considerations for Next-Generation Eosinophil-Targeting Strategies

Joanne C. Masterson et al.

Summary: Eosinophils play crucial roles in gastrointestinal diseases, with diverse functional sub-phenotypes shaped by environmental pressures impacting disease outcomes. Understanding and targeting these sub-phenotypes may be key in developing next-generation treatments for inflammatory eosinophil functions while maintaining homeostatic roles.

CELLS (2021)

Add to Collection

Review Immunology

Understanding mast cell heterogeneity at single cell resolution

Gokhan Cildir et al.

Summary: Mast cells are tissue-resident immune cells with diverse roles in various health conditions, and recent advancements in single-cell technologies have allowed for a better understanding of their development and functional characteristics. These new insights may pave the way for future research directions and therapeutic opportunities in targeting mast cell heterogeneity.

TRENDS IN IMMUNOLOGY (2021)

Add to Collection

Article Multidisciplinary Sciences

The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments

Ricardo Grieshaber-Bouyer et al.

Summary: Neutrophils exhibit a single developmental spectrum, ranging from immature pre-neutrophils in the bone marrow to mature neutrophils in the blood and spleen. Inflammation affects neutrophil transcriptional states, leading to varying transcriptional activities at different sites.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Immunology

Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease

Kevin Mulder et al.

Summary: This study integrated a large number of mononuclear phagocytes from 13 tissues to generate a MNP single-cell RNA compendium, revealing conserved gene signatures and specialized cell subsets across multiple tissues. Specific macrophage populations were found to be expanded in cancer and inflammation, with tumor-associated macrophage populations present in all neoplastic tissues.

IMMUNITY (2021)

Add to Collection

Article Immunology

Single-Cell Analysis Reveals the Heterogeneity of Monocyte-Derived and Peripheral Type-2 Conventional Dendritic Cells

Yuehan Gao et al.

Summary: The study identified different subtypes within human moDCs and blood DCs, revealing their transcriptomic differences and differentiation trajectories, which will enable more accurate functional and developmental analyses of human cDC2s and moDCs.

JOURNAL OF IMMUNOLOGY (2021)

Add to Collection

Article Multidisciplinary Sciences

Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma

Andrea Cugurra et al.

Summary: The meninges contain a pool of monocytes and neutrophils supplied by adjacent skull and vertebral bone marrow, rather than by the blood. Under pathological conditions, CNS-infiltrating myeloid cells can originate from the brain borders and have distinct transcriptional signatures from their blood-derived counterparts. Therefore, myeloid cells from adjacent bone marrow niches are strategically placed to supply innate immune cells under both homeostatic and pathological conditions.

SCIENCE (2021)

Add to Collection

Review Immunology

Genetic models of human and mouse dendritic cell development and function

David A. Anderson et al.

Summary: Genetic models of mouse DC development have helped in understanding the functions of different DC subsets, with classical DCs having specific roles in pathogen detection and cytokine production, while plasmacytoid DCs mainly detect viral infections and produce type I interferon.

NATURE REVIEWS IMMUNOLOGY (2021)

Add to Collection

Article Multidisciplinary Sciences

Lineage tracing on transcriptional landscapes links state to fate during differentiation

Caleb Weinreb et al.

SCIENCE (2020)

Add to Collection

Article Cardiac & Cardiovascular Systems

Deep Phenotyping by Mass Cytometry and Single-Cell RNA-Sequencing Reveals LYN-Regulated Signaling Profiles Underlying Monocyte Subset Heterogeneity and Lifespan

Morgan E. Roberts et al.

CIRCULATION RESEARCH (2020)

Add to Collection

Review Immunology

Establishment and Maintenance of the Macrophage Niche

Martin Guilliams et al.

IMMUNITY (2020)

Add to Collection

Article Immunology

Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection

Cedric Bosteels et al.

IMMUNITY (2020)

Add to Collection

Article Immunology

Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis

Jason S. Seidman et al.

IMMUNITY (2020)

Add to Collection

Article Immunology

Neutrophils Recirculate through Lymph Nodes to Survey Tissues for Pathogens

Ania Bogoslowski et al.

JOURNAL OF IMMUNOLOGY (2020)

Add to Collection

Article Immunology

Merocytic Dendritic Cells Compose a Conventional Dendritic Cell Subset with Low Metabolic Activity

Cindy Audiger et al.

JOURNAL OF IMMUNOLOGY (2020)

Add to Collection

Article Multidisciplinary Sciences

A conserved dendritic-cell regulatory program limits antitumour immunity

Barbara Maier et al.

NATURE (2020)

Add to Collection

Article Multidisciplinary Sciences

Mouse models of neutropenia reveal progenitor-stage-specific defects

David E. Muench et al.

NATURE (2020)

Add to Collection

Article Neurosciences

Profiling peripheral nerve macrophages reveals two macrophage subsets with distinct localization, transcriptome and response to injury

Elke Ydens et al.

NATURE NEUROSCIENCE (2020)

Add to Collection

Article Immunology

Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells

Pierre Bourdely et al.

IMMUNITY (2020)

Add to Collection

Review Immunology

Determinants of Resident Tissue Macrophage Identity and Function

Camille Bleriot et al.

IMMUNITY (2020)

Add to Collection

Article Immunology

Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor

Immanuel Kwok et al.

IMMUNITY (2020)

Add to Collection

Article Immunology

Differential IRF8 Transcription Factor Requirement Defines Two Pathways of Dendritic Cell Development in Humans

Urszula Cytlak et al.

IMMUNITY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Co-option of Neutrophil Fates by Tissue Environments

Ivan Ballesteros et al.

CELL (2020)

Add to Collection

Article Immunology

Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection

Xuemei Xie et al.

NATURE IMMUNOLOGY (2020)

Add to Collection

Article Immunology

Coexpression of CD71 and CD117 Identifies an Early Unipotent Neutrophil Progenitor Population in Human Bone Marrow

Huy Q. Dinh et al.

IMMUNITY (2020)

Add to Collection

Article Multidisciplinary Sciences

Mass Cytometry Phenotyping of Human Granulocytes Reveals Novel Basophil Functional Heterogeneity

Nora Vivanco Gonzalez et al.

ISCIENCE (2020)

Add to Collection

Article Immunology

Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species

Rapolas Zilionis et al.

IMMUNITY (2019)

Add to Collection

Article Immunology

Plasmacytoid dendritic cells develop from Ly6D+ lymphoid progenitors distinct from the myeloid lineage

Regine J. Dress et al.

NATURE IMMUNOLOGY (2019)

Add to Collection

Article Immunology

Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells

Charles-Antoine Dutertre et al.

IMMUNITY (2019)

Add to Collection

Article Multidisciplinary Sciences

Phenotypically distinct neutrophils patrol uninfected human and mouse lymph nodes

Laurence S. C. Lok et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity

Chrysothemis C. Brown et al.

CELL (2019)

Add to Collection

Article Cell Biology

Integrated Cross-Species Analysis Identifies a Conserved Transitional Dendritic Cell Population

Rebecca Leylek et al.

CELL REPORTS (2019)

Add to Collection

Article Immunology

Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors

Mar Cabeza-Cabrerizo et al.

SCIENCE IMMUNOLOGY (2019)

Add to Collection

Article Immunology

Heterogeneity of neutrophils

Lai Guan Ng et al.

NATURE REVIEWS IMMUNOLOGY (2019)

Add to Collection

Article Immunology

Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions

Maximilien Evrard et al.

IMMUNITY (2018)

Add to Collection

Article Microbiology

An unappreciated role for neutrophil-DC hybrids in immunity to invasive fungal infections

J. Scott Fites et al.

PLOS PATHOGENS (2018)

Add to Collection

Article Immunology

Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes

Alberto Yanez et al.

IMMUNITY (2017)

Add to Collection

Article Immunology

Splenic Ly6Ghigh mature and Ly6Gint immature neutrophils contribute to eradication of S-pneumoniae

Justin F. Deniset et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Add to Collection

Article Multidisciplinary Sciences

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

Alexandra-Chloe Villani et al.

SCIENCE (2017)

Add to Collection

Article Immunology

CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses

Shu Zhen Chong et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2016)

Add to Collection

Review Immunology

New insights into basophil heterogeneity

Landon K. Oetjen et al.

SEMINARS IN IMMUNOPATHOLOGY (2016)

Add to Collection

Article Oncology

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: N1 versus N2 TAN

Zvi G. Fridlender et al.

CANCER CELL (2009)

Add to Collection

Article Immunology

Three different neutrophil subsets exhibited in mice with different susceptibilities to infection by methicillin-resistant Staphylococcus aureus

Y Tsuda et al.

IMMUNITY (2004)

Add to Collection

© Peeref 2019-2024. All rights reserved.