Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 73, Issue -, Pages -Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2022.101899
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Funding
- European Research Council [ERC801655, ERC_PoC_963863]
- Israeli Science Foundation [1881/19]
- German-Israeli Foundation for Scientific Research and Development
- Henry Chanoch Krenter Institute for Biomedical Imaging and Genomics
- Minerva
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Genome regulation is governed by the dynamics of chromatin modifications, and understanding the complexity of epigenetic combinations is crucial for normal genome regulation and cancer research. The development of novel methodologies has enabled the measurement and characterization of these combinations.
Genome regulation is governed by the dynamics of chromatin modifications. The extensive and diverse array of DNA and histone modifications allow multiple elements to act outcomes. Yet, our ability to elucidate these complex combinations and link them to normal genome regulation, as well as understand their deregulation in cancer, has been hindered by the lack of suitable technologies. Here, we describe recent findings indicating the importance of the combinatorial epigenome, and novel methodologies to measure and characterize these combinations. These complementary methods span multiple disciplines, providing a means to decode epigenetic combinations and link them to biological outcomes. Finally, we discuss the promise of harnessing the rich combinatorial epigenetic information to improve cancer diagnostics and monitoring.
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