4.4 Review

Long-Term Cardiovascular Effects of COVID-19: Emerging Data Relevant to the Cardiovascular Clinician

Journal

CURRENT ATHEROSCLEROSIS REPORTS
Volume 24, Issue 7, Pages 563-570

Publisher

CURRENT MEDICINE GROUP
DOI: 10.1007/s11883-022-01032-8

Keywords

COVID-19; Cardiovascular complications; Post-acute COVID complications; Long COVID

Funding

  1. Mentored PatientOriented Research Career Development Award through the National Heart, Lung, and Blood Institute [K23HL150159]
  2. Amarin Pharma, Inc.
  3. Abbott
  4. Esperion
  5. Edwards Lifesciences
  6. Novartis

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This review consolidates available data on the long-term cardiovascular complications of COVID-19 infection. Acute cardiovascular complications include myocarditis, pericarditis, acute coronary syndrome, heart failure, pulmonary hypertension, right ventricular dysfunction, and arrhythmia. Long-term follow-up shows increased incidence of arrhythmia, heart failure, acute coronary syndrome, right ventricular dysfunction, myocardial fibrosis, hypertension, and diabetes mellitus. Future research is important in understanding the clinical significance of these structural abnormalities and evaluating the effect of vaccines on preventing long-term cardiovascular complications.
Purpose of Review COVID-19 is now a global pandemic and the illness affects multiple organ systems, including the cardiovascular system. Long-term cardiovascular consequences of COVID-19 are not yet fully characterized. This review seeks to consolidate available data on long-term cardiovascular complications of COVID-19 infection. Recent Findings Acute cardiovascular complications of COVID-19 infection include myocarditis, pericarditis, acute coronary syndrome, heart failure, pulmonary hypertension, right ventricular dysfunction, and arrhythmia. Long-term follow-up shows increased incidence of arrhythmia, heart failure, acute coronary syndrome, right ventricular dysfunction, myocardial fibrosis, hypertension, and diabetes mellitus. There is increased mortality in COVID-19 patients after hospital discharge, and initial myocardial injury is associated with increased mortality. Emerging data demonstrates increased incidence of cardiovascular illness and structural changes in recovered COVID-19 patients. Future research will be important in understanding the clinical significance of these structural abnormalities, and to determine the effect of vaccines on preventing long-term cardiovascular complications.

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