Crystal Engineering under Hydrothermal Conditions: Cocrystals and Reactions of 3-Cyanopyridine with Glutaric Acid

Crystallization under hydrothermal conditions is an interesting method to selectively influence crystallization pathways and processes. Crystallization of 3-cyanopyridine and glutaric acid from aqueous solutions under ambient conditions leads to the 2:1 cocrystalline entity 1 of 3-cyanopyridine and glutaric acid. Crystallizations under thermal and hydrothermal conditions lead, depending on the amounts of water used, to both the polymorphic forms 1 and 2 of the 2:1 cocrystalline entity of 3-cyanopyridine and glutaric acid and furthermore to the cocrystalline entity nicotinamide and glutaric acid.

Automated summary

Crystallization under hydrothermal conditions is an interesting method to selectively influence crystallization pathways and processes. The crystallization of 3-cyanopyridine and glutaric acid from aqueous solutions under ambient conditions resulted in the formation of the 2:1 cocrystalline entity 1. Crystallizations under thermal and hydrothermal conditions, depending on the amounts of water used, led to the polymorphic forms 1 and 2 of the 2:1 cocrystalline entity of 3-cyanopyridine and glutaric acid, as well as the cocrystalline entity of nicotinamide and glutaric acid.