Journal
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
Volume 63, Issue 26, Pages 7945-7982Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10408398.2022.2053058
Keywords
Lactocrine programming; lactational programming; cognition; behavior; human milk composition; milk bioactives
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Human milk is a complex liquid food that is customized to meet the needs of infants. The non-nutrient bioactives in milk have an impact on child cognitive and behavioral development, a process known as 'Lactocrine Programming'. This review discusses the links between human milk composition and child cognitive and behavioral development, and provides recommendations for future studies.
Human milk is a highly complex liquid food tailor-made to match an infant's needs. Beyond documented positive effects of breastfeeding on infant and maternal health, there is increasing evidence that milk constituents also impact child neurodevelopment. Non-nutrient milk bioactives would contribute to the (long-term) development of child cognition and behavior, a process termed 'Lactocrine Programming'. In this review we discuss the current state of the field on human milk composition and its links with child cognitive and behavioral development. To promote state-of-the-art methodologies and designs that facilitate data pooling and meta-analytic endeavors, we present detailed recommendations and best practices for future studies. Finally, we determine important scientific gaps that need to be filled to advance the field, and discuss innovative directions for future research. Unveiling the mechanisms underlying the links between human milk and child cognition and behavior will deepen our understanding of the broad functions of this complex liquid food, as well as provide necessary information for designing future interventions.
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