Journal
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
Volume 63, Issue 27, Pages 8768-8780Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10408398.2022.2062294
Keywords
Allergic diseases; dendritic cells; immune regulation; probiotic polysaccharides
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Probiotic-derived polysaccharide capsules have a significant impact on regulating the immune system and alleviating allergic diseases. They can modulate the Th1/Th2 balance, induce differentiation of T regulatory cells, and activate dendritic cells, thereby providing protection against allergic diseases.
Allergic diseases, derived from the dysregulation of immune tolerance mechanisms, have been rising in the last two decades. Recently, increasing evidence has shown that probiotic-derived polysaccharide capsules exhibit a protective effect against allergic diseases, involving regulation of Th1/Th2 balance, induction of differentiation of T regulatory cells and activation of dendritic cells (DCs). DCs have a central role in controlling the immune response through their interaction with gut microbiota via their pattern recognition receptors, including Toll-like receptors and C-type-lectin receptors. This review discusses the effects and critical mechanism of probiotic-derived polysaccharide capsules in regulating the immune system to alleviate allergic diseases. We first describe the development of immune response in allergic diseases and recent relevant findings. Particular emphasis is placed on the effects of probiotic-derived polysaccharide capsules on allergic immune response. Then, we discuss the underlying mechanism of the impact of probiotic-derived polysaccharide capsules on DCs-mediated immune tolerance induction.
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