Journal
CORTEX
Volume 149, Issue -, Pages 73-84Publisher
ELSEVIER MASSON, CORP OFF
DOI: 10.1016/j.cortex.2021.12.014
Keywords
Cerebellum; Frontotemporal dementia; C9orf72; VBM; Cognition
Funding
- National Health and Medical Research Council (NHMRC) of Australia [APP1037746]
- Australian Research Council (ARC) Centre of Excellence in Cognition and its Disorders Memory Program [CE110001021]
- National Construction High-Level University Postgraduate Program [201608200010]
- Appenzeller Neuroscience Fellowship in Alzheimer's Disease, Australia
- NHMRC Career Development Fellowship [FT160100096]
- ARC Future Fellowship [APP1138223]
- NHMRC Boosting Dementia Research Leader-ship Fellowship [GNT1095127]
- NHMRC Dementia Research Team Grant
- NHMRC Senior Leadership Fellow
- NHMRC Senior Research Fellowship
- [GNT1158762]
- [1176607]
- [GNT1103258]
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This study clarifies the impact of C9orf72 repeat expansion on cerebellar integrity in FTD and reveals overlapping patterns of cerebellar atrophy in C9orf72 positive and negative groups. The associations with cognitive functions suggest that the type of pathology linked with cerebellar atrophy is an important variable to consider in future studies.
Background: The GGGGCC hexanucleotide repeat expansion in the non-coding region of the chromosome 9 open reading frame 72 gene (C9orf72) is the most common genetic cause of familial frontotemporal dementia (FTD). This study aims to clarify the patterns of cere-bellar atrophy in FTD patients with and without a C9orf72 repeat expansion compared with healthy controls and determine whether associations between cerebellar atrophy and cognition differ between patient groups.Methods: Thirty C9orf72 repeat expansion-positive FTD patients, 30 C9orf72 repeat expansion-negative FTD patients, and 30 age-, sex-, and education-matched healthy con-trols underwent brain MRI and cognitive assessments. Patient groups were matched for clinical diagnosis, disease duration, general cognition, and disease severity.Results: Compared with controls, the C9orf72 positive group showed cerebellar changes bilaterally involving the lobules V, VI, Crus I, Crus II, VIIb, VIIIa, left VIIIb, and right lobules I-IV. All these changes were localised within the regions affected in the C9orf72 negative group. No significant differences were found between patient groups. Correlation analyses with a liberal threshold found the cerebellar integrity to be associated with attention, language, and executive function in the C9orf72 positive group. In the C9orf72 negative group, these associations included attention, working memory, language, episodic mem-ory, and executive function.Conclusions: This study clarifies the impact of C9orf72 repeat expansion on cerebellar integrity in FTD. The findings reveal overlapping patterns of cerebellar atrophy in C9orf72 positive and negative groups. The associations with cognitive functions suggest that the type of pathology linked with cerebellar atrophy is another relevant variable to consider in future studies.(c) 2022 Elsevier Ltd. All rights reserved.
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