Journal
COMPUTERS IN BIOLOGY AND MEDICINE
Volume 145, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.compbiomed.2022.105402
Keywords
Multiple Sclerosis (MS); Lesion detection; Brain MRI; Segmentation; U-Net; Attention U-Net
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This paper proposes a framework for segmenting lesions of Multiple Sclerosis (MS) using modified U-Net and modified Attention U-Net. By applying preprocessing, modifying the loss function, and using the union of FLAIR and T2 predictions, the performance is significantly improved.
Multiple Sclerosis (MS) is a Central Nervous System (CNS) disease that Magnetic Resonance Imaging (MRI) system can detect and segment its lesions. Artificial Neural Networks (ANNs) recently reached a noticeable performance in finding MS lesions from MRI. U-Net and Attention U-Net are two of the most successful ANNs in the field of MS lesion segmentation. In this work, we proposed a framework to segment MS lesions in FluidAttenuated Inversion Recovery (FLAIR) and T2 MRI images by modified U-Net and modified Attention U-Net. For this purpose, we developed some extra preprocessing on MRI scans, made modifications in the loss function of U-Net and Attention U-Net, and proposed using the union of FLAIR and T2 predictions to reach a better performance. Results show that the union of FLAIR and T2 predicted masks by the modified Attention U-Net reaches the performance of 82.30% in terms of Dice Similarity Coefficient (DSC) in the test dataset, which is a considerable improvement compared to the previous works.
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