Journal
COMPUTERS IN BIOLOGY AND MEDICINE
Volume 143, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.compbiomed.2022.105295
Keywords
Deep learning; Segmentation; CNN
Categories
Funding
- National Cancer Center Research and Development Fund [2020-J-3]
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The current study proposes an auto-segmentation model using a stepwise deep neural network on CT images of head and neck cancer. The results show that the stepwise-network outperforms the atlas-based method and conventional U-net, indicating its potential value in improving the efficiency of head and neck radiotherapy treatment planning.
Objective: The current study aims to propose the auto-segmentation model on CT images of head and neck cancer using a stepwise deep neural network (stepwise-net).Material and methods: Six normal tissue structures in the head and neck region of 3D CT images: Brainstem, optic nerve, parotid glands (left and right), and submandibular glands (left and right) were segmented with deep learning. In addition to a conventional convolutional neural network (CNN) on U-net, a stepwise neural network (stepwise-network) was developed. The stepwise-network was based on 3D FCN. We designed two networks in the stepwise-network. One is identifying the target region for the segmentation with the low-resolution images. Then, the target region is cropped, which used for the input image for the prediction of the segmentation. These were compared with a clinical used atlas-based segmentation.Results: The DSCs of the stepwise-net was significantly higher than the atlas-based method for all organ at risk structures. Similarly, the JSCs of the stepwise-net was significantly higher than the atlas-based methods for all organ at risk structures. The Hausdorff distance (HD) was significantly smaller than the atlas-based method for all organ at-risk structures. For the comparison of the stepwise-net and U-net, the stepwise-net had a higher DSC and JSC and a smaller HD than the conventional U-net.Conclusions: We found that the stepwise-network plays a role is superior to conventional U-net-based and atlas based segmentation. Our proposed model that is a potentially valuable method for improving the efficiency of head and neck radiotherapy treatment planning.
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