Multi-objective design optimization of 3D micro-architected implants

Recent advances in 3D printable micro-architected materials offer unprecedented possibilities for the development of highly tailored orthopaedic implants. These devices, which are typically made from fully solid materials, significantly alter load transmission to the surrounding bone tissue, potentially leading to interface instability and bone resorption. In this work, we present computational methods to synthesize three dimensional (3D), patient-specific, implants with heterogeneous micro-architecture. Our method simultaneously minimizes the risks of load-induced interface fracture and peri-prosthetic bone remodelling, while taking into account functional and manufacturing constraints. We first develop a novel parametric micro-architecture with desirable functional attributes and a wide range of effective mechanical properties, including both positive and negative Poisson's ratios. We then present formulations which optimize the spatial configuration of micro-architecture parameters in order to simultaneously minimize the risk of load-induced interface fracture and post-operative bone remodelling. To that end, a novel bone remodelling objective is devised, taking into account both bone apposition and resorption, predicted via a model based on strain-energy density. The interface fracture objective is defined as the maximum value of the multi-axial Hoffman failure criterion along the interface. The procedure is applied to the design of 3D titanium hip implants with prescribed conventional geometries and compared, in silico, to both a conventional solid implant and a homogeneous low-stiffness lattice design. The optimized implant results in a performance improvement of 64.0% in terms of bone remodelling, and 13.2% in terms of interface fracture risk, compared to a conventional solid implant design. (C) 2022 The Author(s). Published by Elsevier B.Y.

Automated summary

Recent advances in 3D printable micro-architected materials have opened up unprecedented possibilities for highly tailored orthopaedic implants. This study presents computational methods to synthesize patient-specific implants with heterogeneous micro-architecture, aiming to minimize the risks of load-induced interface fracture and post-operative bone remodelling. The optimized implant designs demonstrate significant improvements in bone remodelling and interface fracture risk compared to conventional solid implant designs.