Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 89, Issue -, Pages 105-120Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2015.04.006
Keywords
Pathogen detection; Surface enhanced Raman scattering; Raman microspectroscopy; Classification; Validation; Sample preparation; Extraction; Complex matrices
Categories
Funding
- Fast-TB of Free State of Thuringia [2013FE9057]
- European Union (EFRE)
- RiMaTH [02WRS1276E]
- Fast Diagnosis [13N11350]
- RamaDek [13N11168]
- JCBI 2.0 [03IPT513Y]
- Federal Ministry of Education and Research (BMBF), Germany
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Bacterial detection is a highly topical research area, because various fields of application will benefit from the progress being made. Consequently, new and innovative strategies which enable the investigation of complex samples, like body fluids or food stuff, and improvements regarding the limit of detection are of general interest. Within this review the prospects of Raman spectroscopy as a reliable tool for identifying bacteria in complex samples are discussed. The main emphasis of this work is on important aspects of applying Raman spectroscopy for the detection of bacteria like sample preparation and the identification process. Several approaches for a Raman compatible isolation of bacterial cells have been developed and applied to different matrices. Here, an overview of the limitations and possibilities of these methods is provided. Furthermore, the utilization of Raman spectroscopy for diagnostic purposes, food safety and environmental issues is discussed under a critical view. (C) 2015 Elsevier B.V. All rights reserved.
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