Journal
COMPOSITES PART B-ENGINEERING
Volume 238, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.compositesb.2022.109920
Keywords
Guided bone regeneration; Polymer (textile) fibre; Cure behavior; Micro-mechanics; Mechanical testing
Funding
- National Natural Science Foundation of China [82170990, 81870793]
- Shanghai Science Commission Project [201409006100, 19411950103, 19441902600, 20S31900900, 20DZ2254900, SHDC2020CR5015, SHDC2020CR2042B]
- Shanghai Municipal Planning Commission of Science and Research Fund [201940382, 2020MZYS08]
- Shanghai Fifth People's Hospital, Fudan University [RSP-2021/65]
- Sino German Science Foundation Research Exchange Center [2020WYZT03]
- Researchers Supporting Project, King Saud University, Riyadh, Saudi Arabia [2021-fx020301]
- National Advanced Functional Fiber Innovation Center [M-0263]
- INTERNATIONAL COOPERATION of 2021-2022 China and Poland Science and Technology Personnel Exchange Program [17]
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This study reports on a biomaterial formulation that prevents soft tissue migration into bone defects through a barrier membrane, leading to successful bone regeneration. The nanofibrous membrane, encapsulating EGCG, demonstrates desirable properties and sustained release capability, resulting in repair of 70% of the defect area.
Guided bone regeneration through biomaterial-based formulations can prevent soft tissue migration into the bone defect area through a barrier membrane. However, bone regeneration requires bioactive external interference. Here, we report a biodegradable electrospun poly -L-lactic acid/gelatin-based nanofibrous membrane encapsulating epigallocatechin gallate (EGCG) within the core, with a smooth profile, desirable physicochemical properties, biocompatibility, antibacterial effects, sufficient osteoinductive capability, and sustained EGCG release over one week. 70% of the defect area was repaired with the help of the EGCG-loaded membrane, approximately 1.5-fold improvement over the control group in 8 weeks. In conclusion, these membranes are promising candidates for guided bone regeneration.
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