A Case Report of Burkholderia mallei Infection Leading to Pneumonia

Article Infectious Diseases

The prevalence of diabetes among tuberculosis patients in Denmark

Franziska Grundtvig Huber et al.

Summary: The study aimed to determine the prevalence of diabetes mellitus among tuberculosis patients in Denmark from 2009 to 2014. Results showed that 5.0% of the patients had diabetes, with older age, more comorbidities, non-Danish origin, and higher mortality rates. Patients with low socioeconomic status and those from Greenland had a surprisingly low prevalence of diabetes.

BMC INFECTIOUS DISEASES (2022)

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Article Infectious Diseases

Development of a sensitive competitive enzyme-linked immunosorbent assay for serodiagnosis of Burkholderia mallei, a Tier 1 select agent

Ulrich Wernery et al.

Summary: In this study, a competitive enzyme-linked immunosorbent assay (cELISA) was developed for the detection of Burkholderia mallei infection, showing high sensitivity and specificity in different animals. This test can help in early detection and diagnosis of clinical cases, as well as screening apparently asymptomatic animals, which is beneficial in controlling the spread of glanders.

PLOS NEGLECTED TROPICAL DISEASES (2021)

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Article Microbiology

Proteomic Analysis of Non-human Primate Peripheral Blood Mononuclear Cells During Burkholderia mallei Infection Reveals a Role of Ezrin in Glanders Pathogenesis

Chih-Yuan Chiang et al.

Summary: Burkholderia mallei, the causative agent of glanders, poses a serious biological threat due to its infectivity, antibiotic resistance, and lack of approved vaccines. Studying host responses in non-human primates has revealed insights into the pathogenesis of glanders. Integration of proteomics data has led to the construction of a predictive protein-protein interaction network, shedding light on the molecular mechanisms underlying B. mallei infections.

FRONTIERS IN MICROBIOLOGY (2021)

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Article Immunology

Comparison of three non-human primate aerosol models for glanders, caused by Burkholderia mallei

David M. Waag et al.

Summary: Burkholderia mallei is a gram-negative animal pathogen causing glanders, a contagious and potentially fatal disease. Humans can also be infected, with a wide range of clinical forms, making treatment complicated. Developing effective medical countermeasures requires well-characterized animal models, with the African green monkey identified as optimal for acute glanders infection.

MICROBIAL PATHOGENESIS (2021)

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Article Pathology