Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 213, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2022.112380
Keywords
Aedes aegypti; Stabilized system; Vector control; Larvicidal activity; Artemia sp
Funding
- Coordenacao de Aperfeicoamento de Pessoal de Novel Superior (CAPES)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Laboratorio Nacional de Luz Sincrotron (LNLS) at Centro Nacional de Pesquisa em Energia e Materiais (CNPEM)
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Aedes aegypti is a major public health problem, responsible for spreading epidemics worldwide. A stable system with biological activity against Aedes aegypti larvae was discovered. This system exhibited no toxicity to non-target organisms and showed higher potency as an alternative to commercial larvicides.
Aedes aegypti is currently a major public health problem. This mosquito is responsible for the spread of infectious diseases that have been causing epidemics worldwide. Surfactant-stabilized systems, such as microemulsions, liquid-crystalline precursors and liquid crystals, are promising sustained delivery formulations of hydrophilic and hydrophobic substances. These systems are biocompatible water-soluble reservoirs for N-tosylindole exhibiting biological activity against Aedes aegypti Linn. (Diptera: Culicidae) larvae. The ternary diagram displayed four regions: microemulsion (ME), liquid crystal (LC), emulsion (EM) and phase separation (PS). PLM and SAXS distinguished microemulsions, lamellar and hexagonal phase liquid crystals. The system had a lethal concentration of 50% (LC50 = 0.1 ppm, 0.36 mu M) lower than pure N-tosylindole (0.24 ppm, 0.88 mu M), which has limitations in aqueous media. Furthermore, the formulation displayed no toxicity to Artemia sp., a non-target organism. The system exhibited excellent larvicidal activity as an alternative to commercial larvicides that have shown resistance and toxicity to the environment by Ae. aegypti larvae due to prolonged use. In addition, a two-fold increase in potency was observed.
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