Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 213, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2022.112410
Keywords
In situ polymerization; PEDOT; Neural interface; Neural cells; Cellular response
Funding
- National Natural Science Foundation of China, China [21763004]
- Natural Science Founda-tion of Guangxi Province, China [2016GXNSFBA380053]
- Na-tional Research Foundation of Korea (NRF) grant, Korea [NRF-2020M3C1B8016137]
- National Research Foundation of Korea [2020M3C1B8016137] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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This study investigated the immediate and long-term cellular response to in-situ polymerization of conductive polymers by directly polymerizing them around living neural cells. The experimental findings provide information on the feasibility of this technique in practical applications.
Conducting polymer has been directly polymerized around living neural cells or in the cortex with the aim of creating an intimate contact between implantable electrical devices and electrogenetic cells. The long term cellular effect after conductive polymer coating, a critical issue for practical applications, has not been reported. In this study, poly(3,4-ethylenedioxythiophene) PEDOT was directly polymerized around the living primary neural and PC12 cells under varying current densities, potentials and charge-balanced current pulses. The cell morphology, nuclei evolution, and cell viability post PEDOT polymerization were studied at different time points. The aim of this study was to investigate the immediate and long-term cellular response towards in-situ polymerization of conductive polymers and to provide experimental information on the feasibility of this technique in practical applications.
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