Journal
CLINICAL MICROBIOLOGY REVIEWS
Volume 35, Issue 2, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/cmr.00152-21
Keywords
congenital Chagas disease; Trypanosoma cruzi; diagnosis; health policies; endemic; nonendemic
Categories
Funding
- Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR) (Catalonia, Spain) [2017 SGR 00924]
- Tropical Disease Cooperative Research Network (RICET) (Spain) [RD16/0027/0004]
- Spanish Ministry of Science, Innovation, and Universities through the Centro de Excelencia Severo Ochoa 2019-2023 Program [CEX2018-000806-S]
- FEDER funds
Ask authors/readers for more resources
Population movements have made Chagas disease a global public health issue. Despite efforts to control transmission in Latin American countries where the disease is endemic, congenital Chagas disease remains a significant challenge.
Population movements have turned Chagas disease (CD) into a global public health problem. Despite the successful implementation of subregional initiatives to control vectorial and transfusional Trypanosoma cruzi transmission in Latin American settings where the disease is endemic, congenital CD (cCD) remains a significant challenge. In countries where the disease is not endemic, vertical transmission plays a key role in CD expansion and is the main focus of its control. Although several health organizations provide general protocols for cCD control, its management in each geopolitical region depends on local authorities, which has resulted in a multitude of approaches. The aims of this review are to (i) describe the current global situation in CD management, with emphasis on congenital infection, and (ii) summarize the spectrum of available strategies, both official and unofficial, for cCD prevention and control in countries of endemicity and nonendemicity. From an economic point of view, the early detection and treatment of cCD are cost-effective. However, in countries where the disease is not endemic, national health policies for cCD control are nonexistent, and official regional protocols are scarce and restricted to Europe. Countries of endemicity have more protocols in place, but the implementation of diagnostic methods is hampered by economic constraints. Moreover, most protocols in both countries where the disease is endemic and those where it is not endemic have yet to incorporate recently developed technologies. The wide methodological diversity in cCD diagnostic algorithms reflects the lack of a consensus. This review may represent a first step toward the development of a common strategy, which will require the collaboration of health organizations, governments, and experts in the field. Population movements have turned Chagas disease (CD) into a global public health problem. Despite the successful implementation of subregional initiatives to control vectorial and transfusional Trypanosoma cruzi transmission in Latin American settings where the disease is endemic, congenital CD (cCD) remains a significant challenge.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available