Journal
CLINICAL INFECTIOUS DISEASES
Volume 75, Issue 1, Pages E289-E292Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciac237
Keywords
Omicron variant; asymptomatic carriage; South Africa; SARS-CoV-2; PWH
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Funding
- National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH) [UM1 AI068614-14, UM1 AI068635, 3UM1AI068618-15S1]
- National Treasury of South Africa
- National Department of Health
- Solidarity Response Fund NPC
- Michael & Susan Dell Foundation
- Elma Vaccines and Immunization Foundation [21-V0001]
- Bill & Melinda Gates Foundation [INV-030342]
- Bill and Melinda Gates Foundation [INV-030342] Funding Source: Bill and Melinda Gates Foundation
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We report a 23% asymptomatic SARS CoV-2 Omicron carriage rate in participants of a clinical trial in South Africa, which is 15 times higher than in previous trials. We also found a strong correlation between lower CD4( + )T-cell counts in HIV-infected individuals and increased odds of being SARS-CoV-2 PCR positive.
We report a 23% asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) Omicron carriage rate in participants being enrolled into a clinical trial in South Africa, 15-fold higher than in trials before Omicron. We also found lower CD4( + )T-cell counts in persons with human immunodeficiency virus (HIV) strongly correlated with increased odds of being SARS-CoV-2 polymerase chain reaction (PCR) positive.
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