Journal
CLINICAL IMMUNOLOGY
Volume 239, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2022.109031
Keywords
Lupus; CD4+T cells; T follicular helper cells; Tregs; Foxp3; CD8+T cells
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T cells play a crucial role in the development of SLE, and their abnormalities provide potential targets for therapeutic intervention.
T helper cells aid B cells with the production of antibodies and thus play a central role in disease development of systemic lupus erythematosus (SLE). Numerous T helper cell abnormalities have been described in SLE patients that contribute to disease pathophysiology and provide suitable targets for therapeutic intervention. In addition, T effector cell also play a less well-defined role in SLE. This review focusses on underlying molecular mechanisms of different T cell alterations in SLE.
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