☆ 4.7 Review

Myeloid-derived suppressor cells in COVID-19: A review

CLINICAL IMMUNOLOGY (2022)

Related references

Note: Only part of the references are listed.

Article Medicine, General & Internal

Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection

Feargal J. Ryan et al.

Summary: A study found that recovered individuals, even those with mild cases, may experience persistent symptoms for months after infection, known as long COVID. An integrated analysis of 69 patients recovering from COVID-19 revealed variations in cellular and gene expression levels that may explain the persistence of these long-term effects.

BMC MEDICINE (2022)

Add to Collection

Article Immunology

Correlation of myeloid-derived suppressor cells with C-reactive protein, ferritin and lactate dehydrogenase levels in patients with severe COVID-19

Ayca Emsen et al.

Summary: This study investigated the relationship between MDSC subsets and severity of COVID-19, finding that PMN-MDSCs, especially immature ones, were associated with severity in severe cases. The findings suggest that MDSCs play a significant role in the pathogenesis of COVID-19.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2022)

Add to Collection

Article Immunology

Low Levels of Granulocytic Myeloid-Derived Suppressor Cells May Be a Good Marker of Survival in the Follow-Up of Patients With Severe COVID-19

Carlos Jimenez-Cortegana et al.

Summary: In patients with severe COVID-19, an increase in myeloid-derived suppressive cells (MDSCs) may contribute to immunosuppression and poor outcomes. By monitoring the levels of MDSCs and other immune cells in ICU patients, researchers found that those who survived had lower levels of granulocytic MDSCs, higher levels of activated lymphocytes, and lower levels of exhausted lymphocytes compared to those who died.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Cell Biology

Emergence of immunosuppressive LOX-1+PMN-MDSC in septic shock and severe COVID-19 patients with acute respiratory distress syndrome

Remy Coudereau et al.

Summary: The study explored the presence of LOX-1+ MDSC in bacterial and viral sepsis, finding significant increases in both patient groups, especially in COVID-19 patients with acute respiratory distress syndrome. The persistence of these cells may contribute to long-lasting immunosuppression in patients.

JOURNAL OF LEUKOCYTE BIOLOGY (2022)

Add to Collection

Review Medical Laboratory Technology

Immune mechanisms in cancer patients that lead to poor outcomes of SARS-CoV-2 infection

Muhammad Bilal Latif et al.

Summary: Cancer patients have been significantly affected by the COVID-19 pandemic. The immune dysfunction in cancer patients leads to distinct trajectories of SARS-CoV-2 infection in different types of cancers. Understanding the immune mechanisms associated with the outcomes of SARS-CoV-2 infection in cancer patients can help identify high-risk individuals and develop immune-based preventive measures.

TRANSLATIONAL RESEARCH (2022)

Add to Collection

Article Medicine, Research & Experimental

Role of myeloid-derived suppressor cells in viral respiratory infections; Hints for discovering therapeutic targets for COVID-19

Khadijeh Koushki et al.

Summary: The expansion of myeloid-derived suppressor cells (MDSCs) is enhanced during pathological conditions such as viral respiratory infections, with evidence showing an accumulation of MDSCs in severe stages of COVID-19. MDSCs delay virus clearance through inhibiting T-cell responses, leading to significant pathogenic effects on severe forms of COVID-19. Targeting MDSCs may help reactivate T-cell immunity to prevent severe stages of the disease.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Add to Collection

Article Immunology

SARS-CoV-2-Induced ARDS Associates with MDSC Expansion, Lymphocyte Dysfunction, and Arginine Shortage

Florian Reizine et al.

Summary: The study revealed that ARDS patients with COVID-19 had increased MDSC and decreased CD8(pos) effector memory cell compared to patients with moderate COVID-19 pneumonia. The expansion of COVID-19-related MDSC was directly correlated to lymphopenia and enhanced arginase activity. T cell proliferative capacity in vitro was significantly reduced among COVID-19 patients but could be restored through arginine supplementation.

JOURNAL OF CLINICAL IMMUNOLOGY (2021)

Add to Collection

Review Cell Biology

COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation

Mohamed M. Aboudounya et al.

Summary: Mortality in COVID-19 is caused by respiratory failure, heart failure, and sepsis/multiorgan failure. TLR4, an innate immune receptor, recognizes viral proteins and triggers immune responses. SARS-CoV-2 binds to TLR4, potentially leading to inflammation and multi-organ injury.

MEDIATORS OF INFLAMMATION (2021)

Add to Collection

Review Medical Laboratory Technology

Strategies to DAMPen COVID-19-mediated lung and systemic inflammation and vascular injury

Christian Bime et al.

Summary: Approximately 15%-20% of COVID-19-infected patients progress to severe pneumonia requiring supplemental oxygen, with 5% developing ARDS and multiorgan failure. Despite mortality rates exceeding 40%, there are still unmet needs in understanding the pathology of COVID-19-induced ARDS and developing effective therapies targeting innate immunity-driven inflammation. Some of these unmet needs include predicting hyperinflammatory viral host responses and addressing disease heterogeneity in ARDS, as well as the lack of clinically-useful biomarkers for ARDS.

TRANSLATIONAL RESEARCH (2021)

Add to Collection

Article Cell Biology

MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells

Xin Yin et al.

Summary: Recent studies show that cellular responses to SARS-CoV-2 infection may influence disease severity, with MDA5 and LGP2 primarily regulating IFN induction in lung epithelial cells. Further analysis revealed that viral intermediates specifically activate the IFN response through MDA5-mediated sensing, and transcription factors IRF3, IRF5, and NF-kappa B/p65 play key roles in regulating the IFN response during SARS-CoV-2 infection. These findings provide valuable insights into the molecular mechanisms of innate immune recognition and signaling response to SARS-CoV-2.

CELL REPORTS (2021)

Add to Collection

Review Physiology

Aging, Immunity, and COVID-19: How Age Influences the Host Immune Response to Coronavirus Infections?

Varnica Bajaj et al.

Summary: The novel coronavirus has greatly impacted the world with over 72 million cases and 1.6 million deaths, mostly affecting the elderly population. Aging leads to changes in the immune system, making elderly individuals more susceptible to infections and less responsive to vaccines. Understanding age-related immune system changes is crucial for managing infectious diseases like COVID-19.

FRONTIERS IN PHYSIOLOGY (2021)

Add to Collection

Article Cell Biology

Elevated frequencies of CD14+HLA-DRlo/neg MDSCs in COVID-19 patients

GuoHui Xue et al.

Aging-US (2021)

Add to Collection

Article Cell Biology

Metabolic programs define dysfunctional immune responses in severe COVID-19 patients

Elizabeth A. Thompson et al.

Summary: The study identifies a unique population of T cells expressing increased VDAC1 in severe and recovered COVID-19 patients, associated with mitochondrial dysfunction and apoptosis. Additionally, specific metabolic phenotypes of myeloid-derived suppressor cells in COVID-19 patients can distinguish between severe and mild disease. These findings offer insight into dysfunctional immune response in COVID-19 patients and potential for developing personalized therapeutic approaches.

CELL REPORTS (2021)

Add to Collection

Article Multidisciplinary Sciences

Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2

Catherine F. Hatton et al.

Summary: The innate immune response in epithelial cells following SARS-CoV-2 infection remains unclear. Research using human air-liquid interface culture suggests delayed type I interferon responses compared to other respiratory viruses. The nasal epithelium serves as a likely entry point for virus, and initiating host response. Antiviral interferon responses are crucial in combating SARS-CoV-2, with nasally delivered recombinant IFNs possibly a preventive strategy.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Immunology

Reduced Expression of Autophagy Markers and Expansion of Myeloid-Derived Suppressor Cells Correlate With Poor T Cell Response in Severe COVID-19 Patients

Sergej Tomic et al.

Summary: Severe COVID-19 is characterized by dysregulated immune response, lymphocytopenia, impaired T cell activation, and increased inflammation. Factors such as down-regulated IRF-8 and autophagy-related genes expression, and expansion of MDSC subsets play critical roles in dysregulating T cell response in COVID-19. The findings could have implications in diagnostics and design of novel therapeutics for this disease.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Article Immunology

Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19

Ryan S. Thwaites et al.

Summary: The study found that levels of inflammatory cytokines and chemokines gradually increased with the severity of COVID-19, with IL-6 and GM-CSF playing central roles in the pathogenesis of the disease. Comparisons with samples from fatal influenza patients revealed that GM-CSF was prominent only in COVID-19, further identifying key factors that characterize and distinguish severe and fatal COVID-19.

SCIENCE IMMUNOLOGY (2021)

Add to Collection

Article Immunology

The Dynamic Immunological Parameter Landscape in Coronavirus Disease 2019 Patients With Different Outcomes

Guoxing Tang et al.

Summary: This study reveals that COVID-19 deceased patients exhibit immune dysregulation, including increased neutrophils and IL-6, sustained low levels of CD8(+) T cells, NK cells, and dendritic cells. Among the immunological parameters, M-MDSCs show the best performance in predicting COVID-19 mortality.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Article Immunology

Mild and Asymptomatic COVID-19 Convalescents Present Long-Term Endotype of Immunosuppression Associated With Neutrophil Subsets Possessing Regulatory Functions

Izabela Sieminska et al.

Summary: The study found that even in COVID-19 convalescents with mild or asymptomatic infection, the levels of LDNs/PMN-MDSCs remained elevated in the blood 3 months after infection, negatively correlating with CD8(+) and double-negative T cells. Additionally, these cells were found to affect the production of anti-SARS-CoV-2 S1 neutralizing antibodies.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Article Medicine, Research & Experimental

Functional monocytic myeloid-derived suppressor cells increase in blood but not airways and predict COVID-19 severity

Sara Falck-Jones et al.

Summary: The frequency of M-MDSCs is elevated in the blood of patients with COVID-19, suppressing T cells and strongly associated with disease severity.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Add to Collection

Article Biology

Deep dissection of the antiviral immune profile of patients with COVID-19

Djordje Atanackovic et al.

Summary: The study screened COVID-19 patients for antibodies against 9 different SARS-CoV-2 proteins, identifying immune responses in high-risk patients with significantly higher levels of certain antibodies and transforming growth factor beta, as well as lower levels of specific T cell expression. These findings aid in understanding humoral immune responses against SARS-CoV-2 variants and can assist in designing more effective immunomonitoring methods for COVID-19 vaccines.

COMMUNICATIONS BIOLOGY (2021)

Add to Collection

Article Immunology

RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells

Taisho Yamada et al.

Summary: Efficient immune responses against viral infection are determined by sufficient activation of nucleic acid sensor-mediated innate immunity. RIG-I plays a distinctive role as a restraining factor in the early phase of SARS-CoV-2 infection in human lung cells by recognizing the 3' untranslated region of the viral genome and inhibiting viral replication.

NATURE IMMUNOLOGY (2021)

Add to Collection

Review Immunology

Interleukin-6, CXCL10 and Infiltrating Macrophages in COVID-19-Related Cytokine Storm: Not One for All But All for One!

Francesca Coperchini et al.

Summary: SARS-COV-2 virus leads to a devastating pandemic, with cytokine-storm being a peculiar aspect of infection causing severe respiratory damage and multi-organ failure. IL-6, CXCL10, and macrophages play critical roles in the aberrant immune response, highlighting the importance of their interplay in the onset and progression of the cytokine storm in COVID-19.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Letter Cell Biology

SARS-CoV-2 cell tropism and multiorgan infection

Jia Liu et al.

CELL DISCOVERY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

SARS-CoV-2 sensing by RIG-I and MDA5 links epithelial infection to macrophage inflammation

Lucy G. Thorne et al.

Summary: SARS-CoV-2 infection leads to broad-spectrum immunopathological diseases, exacerbated by inflammatory co-morbidities. Research shows that the virus replicates rapidly in lung epithelial cells and triggers a robust innate immune response, affecting macrophage activation through inflammatory mediators produced during infection. Further exacerbation of the local inflammatory environment occurs when macrophages or epithelial cells are primed with exogenous inflammatory stimuli.

EMBO JOURNAL (2021)

Add to Collection

Review Genetics & Heredity

Role of DAMPs in respiratory virus-induced acute respiratory distress syndrome-with a preliminary reference to SARS-CoV-2 pneumonia

Walter Gottlieb Land

Summary: Cytokine storm plays a crucial role in the severity of COVID-19 outcomes, while DAMPs act similarly by activating inflammatory pathways. Excessive release of DAMPs can lead to dysregulated hyperinflammatory responses, exacerbating the condition.

GENES AND IMMUNITY (2021)

Add to Collection

Article Multidisciplinary Sciences

Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease

Melanie Ricke-Hoch et al.

Summary: The study found that SARS-CoV-2, male sex, old age, and sedentary lifestyle increase PGE2 levels, which may reduce early antiviral defenses and promote severe disease courses and multiple infections.

PLOS ONE (2021)

Add to Collection

Article Cell Biology

Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro

Miguel Reyes et al.

Summary: The study found an expanded CD14(+) monocyte state, MS1, in patients with bacterial sepsis and severe COVID-19, with the gene expression program of MS1 correlating with sepsis severity and being up-regulated in monocytes from severe COVID-19 patients. In vitro induction of MS1 cells from healthy bone marrow HSPCs showed that plasma from sepsis or COVID-19 patients could induce myelopoiesis and expression of the MS1 gene program. The study also demonstrated that systemic cytokines such as IL-6 and IL-10 played a role in inducing myelopoiesis during severe bacterial or SARS-CoV-2 infection.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Add to Collection

Article Immunology

Increased Blood Monocytic Myeloid Derived Suppressor Cells but Low Regulatory T Lymphocytes in Patients with Mild COVID-19

Carlos Jimenez-Cortegana et al.

Summary: The study found that COVID-19 patients had a significant increase in peripheral monocytic MDSCs, a decrease in Tregs, an increase in inhibited or exhausted T cells, as well as a decrease in activated T cells compared to healthy controls. Additionally, there was a significant negative correlation between the number of M-MDSCs and the number of activated T cells.

VIRAL IMMUNOLOGY (2021)

Add to Collection

Article Multidisciplinary Sciences

Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity

L. Vanderbeke et al.

Summary: Research indicates that COVID-19 severity is driven by a hyperinflammatory response rather than direct viral damage, with classical monocytes playing a key role in driving the hypercytokinemia. Disease severity correlates with a reduction in T-lymphocytes, particularly affecting CD8+ cells, and neutrophils contribute to tissue damage through amplification of cytokine levels. The findings suggest a myeloid-driven immunopathology in COVID-19.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Critical Care Medicine

Myeloid phenotypes in severe COVID-19 predict secondary infection and mortality: a pilot study

Clemence Marais et al.

Summary: The deregulated host response and myeloid cell phenotypes in severe COVID-19 are associated with secondary infection development and 28- and 60-day mortality in critically ill patients. Further research is needed to confirm the pathophysiology and virology of COVID-19.

ANNALS OF INTENSIVE CARE (2021)

Add to Collection

Article Immunology

Severe COVID-19 Recovery Is Associated with Timely Acquisition of a Myeloid Cell Immune-Regulatory Phenotype

Amelia C. Trombetta et al.

Summary: This study found that the acquisition of an immune-regulatory myeloid cell phenotype may contribute to recovery in severe COVID-19 patients, and therapeutic agents favoring an innate immune system regulatory shift could be the best strategy at this stage.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Article Cell Biology

Expansion of Myeloid Derived Suppressor Cells Contributes to Platelet Activation by L-Arginine Deprivation during SARS-CoV-2 Infection

Alessandra Sacchi et al.

Summary: The study found a close association between MDSC and platelet activation in severe COVID-19 patients, with MDSC inducing platelet activation by reducing L-arginine levels. This reveals a novel role of MDSC in the pathogenesis of COVID-19.

CELLS (2021)

Add to Collection

Review Immunology

Mechanisms Underlying the Role of Myeloid-Derived Suppressor Cells in Clinical Diseases: Good or Bad

Yongtong Ge et al.

Summary: Myeloid-derived suppressor cells (MDSCs) play a crucial role in immune regulation, particularly in cancer. They promote tumor growth and metastasis and have implications for the efficacy of immunotherapy.

IMMUNE NETWORK (2021)

Add to Collection

Article Immunology

Myeloid cell dynamics correlating with clinical outcomes of severe COVID-19 in Japan

Tomohiro Takano et al.

Summary: An expanded myeloid cell compartment is a key feature of severe COVID-19, with polymorphonuclear (PMN)-MDSCs selectively expanding in survivors of severe cases in Japan, positively correlating with IL-8 levels. This transient expansion of PMN-MDSC subset could serve as a predictor of prognosis in severe COVID-19 cases.

INTERNATIONAL IMMUNOLOGY (2021)

Add to Collection

Article Medicine, Research & Experimental

Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis

Jingjiao Li et al.

Summary: This study provides insights into the molecular mechanisms of SARS-CoV-2 pathogenesis by identifying host proteins targeted by the virus and perturbed in COVID-19 patients. The findings suggest a potential link between the upregulation of cellular proteins related to neutrophil activation, blood coagulation, and downregulation of proteins mediating T cell receptor signaling in severe COVID-19 patients. The interactome analysis further reveals the potential mechanisms by which SARS-CoV-2 triggers cytokine storms through the induction of interleukin-8 and the facilitation of neutrophil chemotaxis.

MED (2021)

Add to Collection

Review Immunology

Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity

Filippo Veglia et al.

Summary: MDSCs are pathologically activated cells with potent immunosuppressive activity, closely associated with poor clinical outcomes in diseases like cancer. Recent studies have identified key distinctions between MDSCs and classical neutrophils and monocytes, providing new insights into therapeutic targeting for cancer and autoimmune diseases through understanding their genomic and metabolic characteristics. Emerging data also suggest potential involvement of MDSCs in pregnancy, neonatal biology, and COVID-19.

NATURE REVIEWS IMMUNOLOGY (2021)

Add to Collection

Article Immunology

Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics

Hamad Alshetaiwi et al.

SCIENCE IMMUNOLOGY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

Alba Grifoni et al.

CELL (2020)

Add to Collection

Article Biochemistry & Molecular Biology

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann et al.

CELL (2020)

Add to Collection

Article Immunology

An Inflammatory Profile Correlates With Decreased Frequency of Cytotoxic Cells in Coronavirus Disease 2019

Veronica Bordoni et al.

CLINICAL INFECTIOUS DISEASES (2020)

Add to Collection

Article Immunology

Antibody Responses to SARS-CoV-2 in Patients With Novel Coronavirus Disease 2019

Juanjuan Zhao et al.

CLINICAL INFECTIOUS DISEASES (2020)

Add to Collection

Letter Medicine, General & Internal

COVID-19: consider cytokine storm syndromes and immunosuppression

Puja Mehta et al.

LANCET (2020)

Add to Collection

Article Oncology

Quantification of Early-Stage Myeloid-Derived Suppressor Cells in Cancer Requires Excluding Basophils

Anm Nazmul H. Khan et al.

CANCER IMMUNOLOGY RESEARCH (2020)

Add to Collection

Article Oncology

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

Zou Xin et al.

FRONTIERS OF MEDICINE (2020)

Add to Collection

Editorial Material Pathology

The spectrum of pathological findings in coronavirus disease (COVID-19) and the pathogenesis of SARS-CoV-2

Rolf F. Barth et al.

DIAGNOSTIC PATHOLOGY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment

Jonas Schulte-Schrepping et al.

CELL (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19

Aymeric Silvin et al.

CELL (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Expansion of myeloid-derived suppressor cells in patients with severe coronavirus disease (COVID-19)

Chiara Agrati et al.

CELL DEATH AND DIFFERENTIATION (2020)

Add to Collection

Editorial Material Immunology

Elevated serum levels of S100A8/A9 and HMGB1 at hospital admission are correlated with inferior clinical outcomes in COVID-19 patients

Liting Chen et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

Add to Collection

Article Hematology

Haematological characteristics and risk factors in the classification and prognosis evaluation of COVID-19: a retrospective cohort study

Danying Liao et al.

LANCET HAEMATOLOGY (2020)

Add to Collection

Article Virology

Type I and Type III IFN Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures

Abigail Vanderheiden et al.

JOURNAL OF VIROLOGY (2020)

Add to Collection

Article Biotechnology & Applied Microbiology

COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis

Robert Lorenz Chua et al.

NATURE BIOTECHNOLOGY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

A single-cell atlas of the peripheral immune response in patients with severe COVID-19

Aaron J. Wilk et al.

NATURE MEDICINE (2020)

Add to Collection

Review Medicine, General & Internal

COVID-19 and comorbidities: a systematic review and meta-analysis

Morgan Spencer Gold et al.

POSTGRADUATE MEDICINE (2020)

Add to Collection

Review Immunology

Immune asynchrony in COVID-19 pathogenesis and potential immunotherapies

Ting Zhou et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

Add to Collection

Article Multidisciplinary Sciences

Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

Prabhu S. Arunachalam et al.

SCIENCE (2020)

Add to Collection

Article Immunology

Re-analysis of Single Cell Transcriptome Reveals That the NR3C1-CXCL8-Neutrophil Axis Determines the Severity of COVID-19

Jang Hyun Park et al.

FRONTIERS IN IMMUNOLOGY (2020)

Add to Collection

Review Immunology

The Development and Homing of Myeloid-Derived Suppressor Cells: From a Two-Stage Model to a Multistep Narrative

Nathan Karin

FRONTIERS IN IMMUNOLOGY (2020)

Add to Collection

Article Oncology

Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation

Luca Cassetta et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Add to Collection

Article Cell Biology

The differential immune responses to COVID-19 in peripheral and lung revealed by single-cell RNA sequencing

Gang Xu et al.

CELL DISCOVERY (2020)

Add to Collection

Review Cardiac & Cardiovascular Systems

Arterial Hypertension as a Risk Comorbidity Associated with COVID-19 Pathology

Alexander Kamyshnyi et al.

INTERNATIONAL JOURNAL OF HYPERTENSION (2020)

Add to Collection

Article Microbiology

Pervasive RNA Secondary Structure in the Genomes of SARS-CoV-2 and Other Coronaviruses

P. Simmonds

MBIO (2020)

Add to Collection

Article Cell Biology

Early expansion of myeloid-derived suppressor cells inhibits SARS-CoV-2 specific T-cell response and may predict fatal COVID-19 outcome

Alessandra Sacchi et al.

CELL DEATH & DISEASE (2020)

Add to Collection

Review Immunology

Immunopathogenesis of SARS-CoV-2-induced pneumonia: lessons from influenza virus infection

Masaaki Miyazawa

INFLAMMATION AND REGENERATION (2020)

Add to Collection

Article Cell Biology

Rapid Generation of Neutralizing Antibody Responses in COVID-19 Patients

Mehul S. Suthar et al.

CELL REPORTS MEDICINE (2020)

Add to Collection

Article Immunology

Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages

Miriam Merad et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Add to Collection

Article Microbiology

Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome

I-Yin Chen et al.

FRONTIERS IN MICROBIOLOGY (2019)

Add to Collection

Review Immunology

Myeloid Derived Suppressor Cells Interactions With Natural Killer Cells and Pro-angiogenic Activities: Roles in Tumor Progression

Antonino Bruno et al.

FRONTIERS IN IMMUNOLOGY (2019)

Add to Collection

Article Multidisciplinary Sciences

VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease

Jeonghan Kim et al.

SCIENCE (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Immunomodulatory Function of Myeloid-Derived Suppressor Cells during B Cell-Mediated Immune Responses

Bilgenaz Ozkan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Add to Collection

Article Immunology

IFNAR1 Controls Autocrine Type I IFN Regulation of PD-L1 Expression in Myeloid-Derived Suppressor Cells

Wei Xiao et al.

JOURNAL OF IMMUNOLOGY (2018)

Add to Collection

Review Immunology

Myeloid-Derived Suppressor Cells: Immune-Suppressive Cells That Impair Antitumor Immunity and Are Sculpted by Their Environment

Suzanne Ostrand-Rosenberg et al.

JOURNAL OF IMMUNOLOGY (2018)

Add to Collection

Review Immunology

Myeloid-derived suppressor cells coming of age

Filippo Veglia et al.

NATURE IMMUNOLOGY (2018)

Add to Collection

Article Virology

Accessory proteins 8b and 8ab of severe acute respiratory syndrome coronavirus suppress the interferon signaling pathway by mediating ubiquitin-dependent rapid degradation of interferon regulatory factor 3

Hui Hui Wong et al.

VIROLOGY (2018)

Add to Collection

Review Immunology

Reactive Oxygen Species as Regulators of MDSC-Mediated Immune Suppression

Kim Ohl et al.

FRONTIERS IN IMMUNOLOGY (2018)

Add to Collection

Article Virology

The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination

Yong Hu et al.

JOURNAL OF VIROLOGY (2017)

Add to Collection

Review Immunology

The Role of Myeloid-Derived Suppressor Cells in Viral Infection

Megan A. O'Connor et al.

VIRAL IMMUNOLOGY (2017)

Add to Collection

Review Oncology

Myeloid-derived suppressor cells as effectors of immune suppression in cancer

Athalia Rachel Pyzer et al.

INTERNATIONAL JOURNAL OF CANCER (2016)

Add to Collection

Article Biochemistry & Molecular Biology

Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction

Danya Ben-Hail et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Add to Collection

Review Multidisciplinary Sciences

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

Vincenzo Bronte et al.

NATURE COMMUNICATIONS (2016)

Add to Collection

Article Immunology

Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients

Thomas Condamine et al.

SCIENCE IMMUNOLOGY (2016)

Add to Collection

Review Immunology

Control of adaptive immunity by the innate immune system

Akiko Iwasaki et al.

NATURE IMMUNOLOGY (2015)

Add to Collection

Article Immunology

PD-L1 is a novel direct target of HIF-1α., and its blockade under hypoxia enhanced MDSC-mediated T cell activation

Muhammad Zaeem Noman et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2014)

Add to Collection

Review Oncology

Pathways mediating resolution of inflammation: when enough is too much

James N. Fullerton et al.

JOURNAL OF PATHOLOGY (2013)

Add to Collection

Article Immunology

Myeloid-Derived Suppressor Cells Evolve during Sepsis and Can Enhance or Attenuate the Systemic Inflammatory Response

Laura Brudecki et al.

INFECTION AND IMMUNITY (2012)

Add to Collection

Article Critical Care Medicine

Myeloid-derived suppressor cells control microbial sepsis

Marc Derive et al.

INTENSIVE CARE MEDICINE (2012)

Add to Collection

Review Transplantation

Generation of myeloid-derived suppressor cells using prostaglandin E-2

Natasa Obermajer et al.

TRANSPLANTATION RESEARCH (2012)

Add to Collection

Article Multidisciplinary Sciences

Increased MDSC Accumulation and Th2 Biased Response to Influenza A Virus Infection in the Absence of TLR7 in Mice

Victoria Jeisy-Scott et al.

PLOS ONE (2011)

Add to Collection

Review Immunology

Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function

Thomas Condamine et al.

TRENDS IN IMMUNOLOGY (2011)

Add to Collection

Review Biochemistry & Molecular Biology

VDAC, a multi-functional mitochondrial protein regulating cell life and death

Varda Shoshan-Barmatz et al.

MOLECULAR ASPECTS OF MEDICINE (2010)

Add to Collection

Article Biochemistry & Molecular Biology

Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer

Srinivas Nagaraj et al.

NATURE MEDICINE (2007)

Add to Collection

Article Hematology

L-arginine availability regulates T-lymphocyte cell-cycle progression

Paulo C. Rodriguez et al.

BLOOD (2007)

Add to Collection

Article Immunology

GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase

DH Munn et al.

IMMUNITY (2005)

Add to Collection

Article Virology

Inhibition of beta interferon induction by severe acute respiratory syndrome coronavirus suggests a two-step model for activation of interferon regulatory factor 3

M Spiegel et al.

JOURNAL OF VIROLOGY (2005)

Add to Collection

© Peeref 2019-2024. All rights reserved.