Lenalidomide and the Expanding Toolkit to Manage Kaposi Sarcoma

Article Oncology

Safety, Activity, and Long-term Outcomes of Pomalidomide in the Treatment of Kaposi Sarcoma among Individuals with or without HIV Infection

Ramya Ramaswami et al.

Summary: Pomalidomide is a safe and effective chemotherapy-sparing agent for the treatment of Kaposi sarcoma in both HIV-positive and HIV-negative patients.

CLINICAL CANCER RESEARCH (2022)

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Review Hematology

KSHV/HHV8-mediated hematologic diseases

Ethel Cesarman et al.

Summary: Kaposi sarcoma herpesvirus (KSHV), also known as human herpesvirus 8, is associated with various lymphoproliferative disorders. KSHV and Epstein-Barr virus (EBV) can infect and transform the same B cell, potentially leading to different diseases. Understanding KSHV biology and clinical features is crucial for targeted therapeutic interventions.

BLOOD (2022)

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Article Oncology

PD-1 blockade with pembrolizumab in classic or endemic Kaposi's sarcoma: a multicentre, single-arm, phase 2 study

Julie Delyon et al.

Summary: PD-1 blockade with pembrolizumab shows promising anti-tumor activity and acceptable safety profile in patients with classic and endemic Kaposi sarcoma.

LANCET ONCOLOGY (2022)

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Article Oncology

AMC-070: Lenalidomide Is Safe and Effective in HIV-Associated Kaposi Sarcoma

Erin G. Reid et al.

Summary: Lenalidomide demonstrates efficacy and tolerability in patients with HIV-KS, making it a potential alternative to standard chemotherapy. Correlative studies suggest that the effects of lenalidomide on T-cell subsets and viral transcription may contribute to its therapeutic effects.

CLINICAL CANCER RESEARCH (2022)

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Article Multidisciplinary Sciences

Update of the global distribution of human gammaherpesvirus 8 genotypes

Amanda de Oliveira Lopes et al.

Summary: Genetic analysis based on ORF-K1 sequences revealed that HHV-8 genotypes A and C are widely distributed in Africa and Europe, with genotype B being predominant in Africa. Rare genotypes D and E were found in East Asia and Oceania/South America, respectively, while genotype F was prevalent in Africa. Brazil in the American continent exhibited the highest genotypic diversity with five HHV-8 genotypes present. This study provides an updated global distribution of HHV-8 genotypes for future epidemiological and evolutionary research.

SCIENTIFIC REPORTS (2021)

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Article Oncology

Kaposi Sarcoma Incidence, Burden, and Prevalence in United States People with HIV, 2000-2015

Sally Peprah et al.

Summary: In the United States, there has been a consistent gradual decline in Kaposi sarcoma (KS) incidence among people with HIV (PWH) during the current cART era. This decrease is uniform across key demographic and HIV transmission groups, though rates remain elevated relative to the general population.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2021)

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Article Medicine, General & Internal